J Korean Ophthalmol Soc.  2017 Apr;58(4):437-442. 10.3341/jkos.2017.58.4.437.

Retinal Nerve Fiber Layer and Macular Ganglion Cell Thicknesses in Situs Inversus of Optic Discs

• Kim MK
• Kim JM
• Hwang YH

• KMID: 2376599
• DOI: http://doi.org/10.3341/jkos.2017.58.4.437

Abstract

PURPOSE
To investigate circumpapillary retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GCIPL) thicknesses as measured by optical coherence tomography in eyes with situs inversus of optic discs.
METHODS
RNFL and macular GCIPL thicknesses were measured in eyes with situs inversus of optic discs without other ocular abnormalities (situs inversus group) and in age- and refractive error-matched healthy eyes (control group). RNFL thickness (global area, superior, nasal, inferior, and temporal quadrants) and GCIPL thickness (global area, superior-temporal, superior, superior-nasal, inferior-nasal, inferior, and inferior-temporal sectors and minimum) were compared between the groups.
RESULTS
Nine eyes of 5 subjects with situs inversus of optic discs and 20 healthy eyes of 20 subjects (10 eyes for control groups A and B, respectively) were enrolled. No significant difference was found in superior or inferior quadrant RNFL thickness (p > 0.05); however, the situs inversus group showed a thicker RNFL in the nasal quadrant and a thinner RNFL in the temporal quadrant (p < 0.01). In macular GCIPL thickness, no significant difference was found in the superotemporal or inferiotemporal sector or for minimum thickness (p < 0.05); however, the situs inversus group showed thicker GCIPL in the global area, superior, superonasal, inferonasal, and inferior sectors than the control groups (p < 0.01).
CONCLUSIONS
In eyes with situs inversus of optic discs, distribution of circumpapillary RNFL and macular GCIPL thickness were different from eyes without this condition. When assessing RNFL and macular GCIPL thicknesses in eyes with situs inversus of optic discs, caution is needed.

Keyword

Optic nerve head; Retinal ganglion cell; Retinal nerve fiber layer; Situs inversus

MeSH Terms

Ganglion Cysts*
Nerve Fibers*
Optic Disk
Retinal Ganglion Cells
Retinaldehyde*
Situs Inversus*
Tomography, Optical Coherence
Retinaldehyde

Figure

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  Figure 1. An example of optic disc in a healthy eye (left col-umn) and an eye with situs inversus of optic disc (right col-umn). Disc photograph (A), red-fee fundus photograph (B), and circumpapillary retinal nerve fiber layer thickness dis-tribution as measured by Cirrus high– definition optical coher-ence tomography(C).

• 

  Figure 2. An example of macular ganglion cell-inner plexi-form layer thickness distribution. Presented by thickness map (A) and sector map (B) of Cirrus high– definition optical co-herence tomography in a healthy eye (left column) and an eye with situs inversus of optic disc (right column) presented in Figure 1.

Reference

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