J Korean Diabetes.  2017 Mar;18(1):53-61. 10.4093/jkd.2017.18.1.53.

The Effect of Pravastatin on Insulin Resistance in Hyperglycemic Patients

• Jeong YJ
• Kim JM
• Jang SJ
• Bang JH
• Jung YG
• Kim ST
• Kang SH
• Choi JI
• Kim SS
• Kang MY

• KMID: 2374769
• DOI: http://doi.org/10.4093/jkd.2017.18.1.53

Abstract

BACKGROUND
The effect of pravastatin on insulin resistance (IR) is controversial and poorly studied in prediabetes.
METHODS
This study was performed in hyperglycemic patients at Saint Carollo Hospital from January 1, 2013 to December 31, 2015. Among them, we selected 40 patients (24 prediabetes and 16 new onset diabetes [NOD]) who had been treated with pravastatin 20 mg daily for 2 or 4 months and in whom fasting insulin and fasting glucose had been measured before and after administration of pravastatin. IR was defined as a fasting insulin level ≥ 12.94 µU/mL, homeostasis model for IR (HOMA-IR) ≥ 3.04 or quantitative insulin sensitivity check index (QUICKI) ≤ 0.32.
RESULTS
Pravastatin treatment decreased total cholesterol and low-density lipoprotein cholesterol levels by 25.2% and 32.3% respectively (P = 0.000 for all), but did not affect fasting insulin level, HOMA-IR, or QUICKI in total, prediabetes, and NOD groups. Prevalence of IR was significantly different between prediabetes and NOD groups both before and after pravastatin treatment (0% versus 37.5%, P = 0.001), but pravastatin treatment did not affect the prevalence of IR in the prediabetes or NOD group. Fasting glucose level was not significantly different before and after pravastatin treatment in prediabetes (106.8 ± 6.4 mg/dL versus 103.8 ± 8.4 mg/dL, P = 0.223) but was significantly different in the NOD group (171.5 ± 70.1 mg/dL versus 124.4 ± 26.7 mg/dL, P = 0.017).
CONCLUSION
Pravastatin treatment did not affect IR or fasting glucose level in hyperglycemic patients. Therefore, we suggest pravastatin can be prescribed to hypercholesterolemic patients with hyperglycemia.

Keyword

Homeostasis model assessment of insulin resistance; Insulin resistance; Pravastatin; Prediabetic state; Quantitive insulin sensitivity check index

MeSH Terms

Cholesterol
Fasting
Glucose
Homeostasis
Humans
Hyperglycemia
Insulin Resistance*
Insulin*
Lipoproteins
Pravastatin*
Prediabetic State
Prevalence
Saints
Cholesterol
Glucose
Insulin
Lipoproteins
Pravastatin

Figure

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  Fig. 1. Fasting insulin level, homeostasis model assessment of insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI) before and after pravastatin treatment. Black, new onset diabetes mellitus; Gray, prediabetes.

Reference

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