J Gynecol Oncol.  2016 Nov;27(6):e53. 10.3802/jgo.2016.27.e53.

Major clinical research advances in gynecologic cancer in 2015

• Suh DH
• Kim M
• Kim HJ
• Lee KH
• Kim JW

• KMID: 2374256
• DOI: http://doi.org/10.3802/jgo.2016.27.e53

Abstract

In 2015, fourteen topics were selected as major research advances in gynecologic oncology. For ovarian cancer, high-level evidence for annual screening with multimodal strategy which could reduce ovarian cancer deaths was reported. The best preventive strategies with current status of evidence level were also summarized. Final report of chemotherapy or upfront surgery (CHORUS) trial of neoadjuvant chemotherapy in advanced stage ovarian cancer and individualized therapy based on gene characteristics followed. There was no sign of abating in great interest in immunotherapy as well as targeted therapies in various gynecologic cancers. The fifth Ovarian Cancer Consensus Conference which was held in November 7-9 in Tokyo was briefly introduced. For cervical cancer, update of human papillomavirus vaccines regarding two-dose regimen, 9-valent vaccine, and therapeutic vaccine was reviewed. For corpus cancer, the safety concern of power morcellation in presumed fibroids was explored again with regard to age and prevalence of corpus malignancy. Hormone therapy and endometrial cancer risk, trabectedin as an option for leiomyosarcoma, endometrial cancer and Lynch syndrome, and the radiation therapy guidelines were also discussed. In addition, adjuvant therapy in vulvar cancer and the updated of targeted therapy in gynecologic cancer were addressed. For breast cancer, palbociclib in hormone-receptor-positive advanced disease, oncotype DX Recurrence Score in low-risk patients, regional nodal irradiation to internal mammary, supraclavicular, and axillary lymph nodes, and cavity shave margins were summarized as the last topics covered in this review.

Keyword

Precision Medicine; Genital Neoplasms, Female; Ovarian Epithelial Cancer; Breast Neoplasms

MeSH Terms

Biomedical Research/*trends
Breast Neoplasms/therapy
Combined Modality Therapy
Dioxoles
Endometrial Neoplasms/therapy
Female
Genital Neoplasms, Female/genetics/*therapy
Humans
Immunotherapy
Neoadjuvant Therapy
Neoplasm Recurrence, Local
Ovarian Neoplasms/prevention & control/therapy
Papillomavirus Vaccines
Precision Medicine
Tetrahydroisoquinolines
Uterine Cervical Neoplasms/prevention & control/therapy/virology
Uterine Neoplasms/therapy
Dioxoles
Papillomavirus Vaccines
Tetrahydroisoquinolines