Yonsei Med J.  2016 Sep;57(5):1185-1191. 10.3349/ymj.2016.57.5.1185.

Therapeutic Efficacy of Oral Enteral Nutrition in Pediatric Crohn's Disease: A Single Center Non-Comparative Retrospective Study

• Kim HJ
• Kim Y
• Cho JM
• Oh SH
• Kim KM

• KMID: 2374164
• DOI: http://doi.org/10.3349/ymj.2016.57.5.1185

Abstract

PURPOSE
Exclusive enteral nutrition (EEN) therapy effectively induces clinical remission in Crohn's disease (CD). It remains unclear, however, whether partial enteral nutrition (PEN) can maintain remission. This study was performed to determine the abilities of oral EEN and oral PEN to induce and maintain clinical remission in pediatric patients with CD, respectively.
MATERIALS AND METHODS
Pediatric patients with CD who received oral EEN at a single center in 2000-2014 were identified retrospectively. Remission rates of the EEN and PEN during the 2 years study period were determined. Risk factors for EEN and PEN failure were identified.
RESULTS
Of the 66 patients who started EEN, 61 (92%) completed the course. Clinical remission was achieved in 88% (58/66) of the patients. All 58 patients with remission continued with PEN: 43 (74%) were treatment adherent. The cumulative remission rates at 1 and 2 years were 67% and 52%, respectively. Differing from EEN, limited therapeutic efficacy of PEN was shown in severe CD patients. Female gender associated significantly with non-adherence.
CONCLUSION
Oral EEN and PEN effectively induced and maintained remission in a pediatric population. Non-adherence was a limiting factor in the success of therapy.

Keyword

Crohn disease; nutrition therapy; remission induction; maintenance; child

MeSH Terms

Adolescent
Child
Crohn Disease/*therapy
Enteral Nutrition/*methods
Female
Humans
Male
Remission Induction
Retrospective Studies

Figure

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  Fig. 1 Clinical remission rate over time of patients (upper curve: partial enteral nutrition-compliant patients, lower curve: all patients) treated with oral induction and maintenance enteral nutrition.

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