Yeungnam Univ J Med.  1986 Dec;3(1):193-199. 10.12701/yujm.1986.3.1.193.

Diagnostic Significance of Total Lactate Dehydrogenase(LD) and LD Isoenzyme Measurement in the Body Fluids

• Jeon CH
• Bae EK
• Hong SI
• Kim CS
• Lee YH

• KMID: 2373881
• DOI: http://doi.org/10.12701/yujm.1986.3.1.193

Abstract

Body fluid Lactate dehydrogenase and its isoenzyme Measurement was performed in 132 patients: 8 cases with peritonitis, 21 cases with malignant ascites, 43 cases with liver cirrhosis, 48 cases with tuberculous pleuritis, 12 cases with malignant pleural effusion respectively. Body fluid protein and glucose contents, red blood cell counts, white blood cell counts, cytologic examination were also performed as a comparative study. The results were as follows: 1. Measurement of total LD and protein amount could differentiate between transudate and exudates in the ascitic fluids. 2. In the malignant exudate of ascites and pleural fluid, the activity of LD2 isoenzyme was statistically increased compared with that of inflammatory exudates and the activity of LD4 isoenzyme was also incereased compared with that of serum (P<0.05). 3. The inflammatory exudates of pleural fluid and ascites demonstrated the increase of LD5 isoenzyme activity statistically compared with that of serum and malignant exudates (P<0.05). 4. A difference of total LD activity between malignant ascites and inflammatory ascites was significant statistically, while this was not observed in the pleural exudate. 5. Total LD and LD5 isoenzyme activity didn't correlated with the number of white blood cells in the exudate.

MeSH Terms

Ascites
Ascitic Fluid
Body Fluids*
Erythrocyte Count
Exudates and Transudates
Glucose
Humans
L-Lactate Dehydrogenase
Lactic Acid*
Leukocyte Count
Leukocytes
Liver Cirrhosis
Peritonitis
Pleural Effusion, Malignant
Pleurisy
Glucose
L-Lactate Dehydrogenase
Lactic Acid