Korean J Occup Environ Med.  1990 Aug;2(2):206-211.

Activities of Serum Lactate Dehydrohenase and Lactate Dehydrogenase Isoenzymes Activities by Small Opacity Groups on Chest Radiographs in Coal Worker's Pneumoconiosis Patients

• chung HD
• Hong JP

Abstract

Serum lactate degydrogenase (LD) and LD isoenzyme activities were evaluated in sera from 74 patients of coal workers' pneumoconiosis (CWP) to investigate biochemical changes of these enzyme activities according to radiographical profusions of CWP. Subjects were participated patients in the detailed examination of pneumoconiosis in December 1989. LD activities were evaluated by lactate to pyruvate methods and isoenzyme activities were determined by agarose gel electrophoresis. And small opacity profusions on chest radiographs of subjects were evaluated by radiologist. The results were as follows: 1. LD activities were not significantly different among categories of radiographical profusions. 2. LD4 activities were shown difference significantly among categories of radiographical profusions (category 1: 8.2+/-2.69 U/l, category 2: 10.1+/-3.90, category 3: 10.6+/-2.63; p<0.05). 3. Activities of LD(1), LD(2), LD(3), and LD(5) were not different significantly among categories of radiographical profusions.
Conclusion
ly, serum LD(4) activity seems to be increased by fibroplasia of CWP, but increasing activities of LD4 should not affect serum LD activities significantly.

Keyword

coal workers' pneumoconiosis; lactate dehydrogenase; lactate dehydrogenase isoenzyme activity

MeSH Terms

Anthracosis*
Coal*
Electrophoresis, Agar Gel
Humans
Isoenzymes*
L-Lactate Dehydrogenase*
Lactic Acid*
Pneumoconiosis
Pyruvic Acid
Radiography, Thoracic*
Thorax*
Coal
Isoenzymes
L-Lactate Dehydrogenase
Lactic Acid
Pyruvic Acid