J Clin Pathol Qual Control.  2000 Jun;22(1):213-218.

Creatine Kinase, Lactate Dehydrogenase and Cardiac Troponin l in Thyroid Disease

• Park PW
• Kim W

Abstract

BACKGROUND: Concentrations of creatine kinase (CK) and lactate dehydrogenase (LD) in serum are increased in patients with hypothyroidism, but evidences for any changes in hyperthyroidism is controversial. The association between hypothyroidism and atherosclerotic cardiovascular disease (ASCVD) has been described for many years. In this study we compare CK, LD activities and its isoenzymes in patients with hypo- and hyperthyroidism. In addition we trying to find the association between ASCVD and thyroid diseases by measuring cardiac troponin I (cTnl).
METHODS
Serum CK and LD activities, its isoenzymes and cTnI were assayed on 20 patients with hypothyroidism, and 55 patients with hyperthyroidism, and 24 individuals as a healthy control group during a period of 4 months in 1999. Medical records were analyzed retrospectively in order to find any evidence of cardiovascular diseases.
RESULTS
Mean CK and LD activities are 206 U/L, 497 U/L in patient with hypothyroidism and 41 U/L, 335 U/L in patients with hyperthyroidism. cTnI was within the reference ranges for all patients, and they have no history of ASCVD.
CONCLUSIONS
CK and LD activities are elevated in patients with hypothyroidism, and shows no statistical differences in patients with hyperthyroidism compared to normal individuals. When evaluating myocardial injury in a hypothyroid patient, cTnI is the superior marker compared to other muscle derived enzymes.

MeSH Terms

Cardiovascular Diseases
Creatine Kinase*
Creatine*
Humans
Hyperthyroidism
Hypothyroidism
Isoenzymes
L-Lactate Dehydrogenase*
Lactic Acid*
Medical Records
Reference Values
Retrospective Studies
Thyroid Diseases*
Thyroid Gland*
Troponin I
Troponin*
Creatine
Creatine Kinase
Isoenzymes
L-Lactate Dehydrogenase
Lactic Acid
Troponin
Troponin I