Korean J Intern Med.
2016 Mar;31(2):386-391. 10.3904/kjim.2015.039.
The role of neutrophil lymphocyte ratio to leverage the differential diagnosis of familial Mediterranean fever attack and acute appendicitis
- Affiliations
-
- 1Division of Rheumatology, Department of Internal Medicine, Necmettin Erbakan University, Konya, Turkey. drademk@yahoo.com
- 2Department of General Surgery, Bursa Sevket Yilmaz Research and Training Hospital, Bursa, Turkey.
- 3Division of Rheumatology, Department of Internal Medicine, Cumhuriyet University, Sivas, Turkey.
- 4Department of Internal Medicine, Cumhuriyet University, Sivas, Turkey.
- 5Department of Physical Medicine and Rehabilitation, Bursa Sevket Yilmaz Research and Training Hospital, Bursa, Turkey.
- 6Department of General Surgery, Necmettin Erbakan University, Konya, Turkey.
- 7Division of Nephrology, Department of Internal Medicine, Necmettin Erbakan University, Konya, Turkey.
- KMID: 2373814
- DOI: http://doi.org/10.3904/kjim.2015.039
Abstract
- BACKGROUND/AIMS
Familial Mediterranean fever (FMF) is an autosomal recessive disorder characterized by attacks of fever and diffuse abdominal pain. The primary concern with this presentation is to distinguish it from acute appendicitis promptly. Thus, we aimed to evaluate the role of neutrophil lymphocyte ratio (NLR) to leverage the differential diagnosis of acute FMF attack with histologically proven appendicitis.
METHODS
Twenty-three patients with histologically confirmed acute appendicitis and 88 patients with acute attack of FMF were included in the study. NLR, C-reactive protein and other hematologic parameters were compared between the groups.
RESULTS
Neutrophil to lymphocyte ratio was significantly higher in patients with acute appendicitis compared to the FMF attack group (8.24 +/- 6.31 vs. 4.16 +/- 2.44, p = 0.007). The performance of NLR in diagnosing acute appendicitis with receiver operating characteristic analysis with a cut-off value of 4.03 were; 78% sensitivity, 62% specificity, and area under the curve 0.760 (95% confidence interval, 0.655 to 0.8655; p < 0.001).
CONCLUSIONS
This study showed that NLR, the simple and readily available inflammatory marker may have a useful role in distinguishing acute FMF attack from acute appendicitis.
Keyword
MeSH Terms
-
Adult
Appendicitis/blood/*diagnosis
Area Under Curve
Biomarkers/blood
Blood Sedimentation
Diagnosis, Differential
Familial Mediterranean Fever/blood/*diagnosis
Female
Humans
Inflammation Mediators/blood
Lymphocyte Count
*Lymphocytes
Male
*Neutrophils
Platelet Count
Predictive Value of Tests
ROC Curve
Reproducibility of Results
Retrospective Studies
Young Adult
Biomarkers
Inflammation Mediators
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- The First Case of Familial Mediterranean Fever Associated with Renal Amyloidosis in Korea
- A Review of WBC Count and Neutrophil/lymphocyte Ratio in Patients with Acute Appendicitis
- Familial Mediterranean fever presenting as fever of unknown origin in Korea
- Can the Thiol/Disulfide Imbalance Be a Predictor of Colchicine Resistance in Familial Mediterranean Fever?
- Review of the Pathology and Differential Diagnosis of Acute Appendicitis
