J Korean Med Sci.  2016 Aug;31(8):1246-1253. 10.3346/jkms.2016.31.8.1246.

Online Registry for Nationwide Database of Current Trend of Helicobacter pylori Eradication in Korea: Interim Analysis

• Kim BJ
• Kim HS
• Song HJ
• Chung IK
• Kim GH
• Kim BW
• Shim KN
• Jeon SW
• Jung YJ
• Yang CH
• Kim JH
• Kim TH
• Kim SG
• Shin WG
• Kim SM
• Han SW
• Lee JH
• Kim KH
• Park SK
• Park BJ
• Lee J
• Kim JG
• Korean College of Helicobacter and Upper Gastrointestinal Research

• KMID: 2373752
• DOI: http://doi.org/10.3346/jkms.2016.31.8.1246

Abstract

Eradication of Helicobacter pylori using first-line therapy is becoming less effective. Subjects who had been treated for H. pylori infection were prospectively enrolled through an on-line database registry from October 2010 to December 2012. Demographic data, detection methods, treatment indication, regimens, durations, compliance, adverse events, and eradication results for H. pylori infection were collected. Data of 3,700 patients from 34 hospitals were analyzed. The overall eradication rate of the first-line therapy was 73.0%. Eradication failure was significantly associated with old age, concomitant medication, and comorbidity. Regional differences in eradication rates were observed. The most common first-line therapy was proton pump inhibitor-based triple therapy (standard triple therapy, STT) for 7 days (86.8%). The eradication rates varied with regimens, being 73% in STT, 81.8% in bismuth-based quadruple therapy, 100% in sequential therapy, and 90.3% in concomitant therapy. The eradication rate in treatment-naïve patients was higher than that in patients previously treated for H. pylori infection (73.8% vs. 58.5%, P < 0.001). The overall eradication rate for second-line therapy was 84.3%. There was no statistical difference in eradication rates among various regimens. H. pylori eradication rate using STT is decreasing in Korea and has become sub-optimal, suggesting the need for alternative regimens to improve the efficacy of first-line therapy for H. pylori infection.

Keyword

Helicobacter pylori; Eradication Success; First-line Therapy; On-line Registry

MeSH Terms

Adult
Age Factors
Aged
Anti-Bacterial Agents/*therapeutic use
Databases, Factual
Drug Therapy, Combination
Female
Helicobacter Infections/*drug therapy/microbiology
Helicobacter pylori/isolation & purification
Humans
Internet
Logistic Models
Male
Middle Aged
Prospective Studies
Proton Pump Inhibitors/*therapeutic use
Registries
Republic of Korea
Treatment Outcome
Anti-Bacterial Agents
Proton Pump Inhibitors

Figure

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  Fig. 1 Helicobacter pylori eradication in first-line and second-line therapy. A total of 3,700 patients participated in the study. First-line and second-line therapy overall eradication rate was 73.0% and 84.3%, respectively.

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  Fig. 2 Standardized Helicobacter pylori eradication rates in first-line therapy according to residence in Korea. The overall eradication rate in seven regions in Korea was 73.0%. Jeju province showed the highest eradication rate in the first-line therapy, whereas Chungcheong province had the lowest (76.1 vs. 60.3, P < 0.001).

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