Nucl Med Mol Imaging.  2017 Mar;51(1):88-92. 10.1007/s13139-016-0428-7.

Primary Pulmonary Lymphoepithelioma-like Carcinoma on FDG PET/CT

• Aktas GE
• Can N
• Demir SS
• Sarıkaya

• KMID: 2373461
• DOI: http://doi.org/10.1007/s13139-016-0428-7

Abstract

A 69-year-old male smoker was referred to ¹â¸F-f luorodeoxyglucose (FDG) pos i t r on emi s sion tomography-computed tomography (PET/CT) with the indication of a suspicious solitary pulmonary nodule. FDG PET/CT determined a 2.5 × 2-cm soft-tissue lesion (SUVmax, 16.2) with spiculated margins in the hilum of the right lung. A 1-cm diameter lymphadenopathy on the right hilum with an SUVmax of 3.2 was also determined. Transbronchial biopsy of the right hilar lymphadenopathy did not reveal any malignant features in histopathologic examination, and it was determined to be reactive. The patient underwent a right upper lobe segmentectomy, and the histopathologic evaluation revealed that the tumor was a primary lymphoepithelioma-like carcinoma (LELC) of the lung with negative Epstein-Barr virus (EBV) on in situ hybridization studies. In this case report, we mainly focus on the FDG avidity of this very rare kind of tumor comparatively with previous reports and possible explanations of discordancy in FDG avidity in relation to histopathologic characteristics.

Keyword

Lymphoepithelioma-like carcinoma; Lung cancer; SUV; FDG; PET/CT

MeSH Terms

Aged
Biopsy
Herpesvirus 4, Human
Humans
In Situ Hybridization
Lung
Lung Neoplasms
Lymphatic Diseases
Male
Mastectomy, Segmental
Positron-Emission Tomography and Computed Tomography*
Solitary Pulmonary Nodule