Korean J Gastroenterol.  2015 Nov;66(5):291-296. 10.4166/kjg.2015.66.5.291.

Primary Adenocarcinoma with Focal Choriocarcinomatous Differentiation in the Sigmoid Colon

Affiliations
  • 1Department of Internal Medicine and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea. mdkhwook@gmail.com
  • 2Department of Internal Medicine, Wallace Memorial Baptist Hospital, Pusan, Korea.

Abstract

Primary colorectal choriocarcinoma is a rare neoplasm. Only 19 cases have been reported worldwide, most of which involved adenocarcinomas. The prognosis is usually poor, and the standard therapy for this tumor has not been established. A 61-year-old woman presented with constipation and lower abdominal discomfort. She was diagnosed with primary adenocarcinoma with focal choriocarcinomatous differentiation in the sigmoid colon and liver metastasis. Because the serum beta-human chorionic gonadotropin level was not significantly elevated, and because only focal choriocarcinomatous differentiation was diagnosed, we selected the chemotherapy regimen that is used for the treatment of metastatic colorectal adenocarcinoma. The patient survived for 13 months after the initial diagnosis. This is the first case in Korea to assess the suppressive effects of the standard chemotherapy for colorectal adenocarcinoma against coexisting colorectal choriocarcinoma and adenocarcinoma.

Keyword

Adenocarcinoma; Choriocarcinoma; Colon; Drug therapy

MeSH Terms

Adenocarcinoma/*diagnosis/drug therapy/pathology
Antineoplastic Agents/administration & dosage
Antineoplastic Combined Chemotherapy Protocols/therapeutic use
CA-19-9 Antigen/analysis
Chorionic Gonadotropin, beta Subunit, Human/blood
Colon, Sigmoid/pathology
Colonic Neoplasms/*diagnosis/drug therapy/pathology
Colonoscopy
Constipation/etiology
Female
Fluorouracil/therapeutic use
Humans
Leucovorin/therapeutic use
Liver Neoplasms/secondary
Middle Aged
Organoplatinum Compounds/therapeutic use
Prognosis
Tomography, X-Ray Computed
Antineoplastic Agents
CA-19-9 Antigen
Chorionic Gonadotropin, beta Subunit, Human
Organoplatinum Compounds
Leucovorin
Fluorouracil
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