J Korean Gastric Cancer Assoc.  2005 Mar;5(1):57-64.

Curative Resection of Inoperable, Locally Advanced Gastric Cancer after Neoadjuvant Chemotherapy with Taxotere and Cisplatin

• Lee HH
• Hur H
• Chae BJ
• Kim W
• Jeon HM

Abstract

At diagnosis, the majority of patients with gastric cancer are found to have local invasion or distant organ metastasis, even though the sole measure for a complete cure is a curative resection. A curative resection is hardly applicable for those with invasion and metastasis; thus, trials with neoadjuvant chemotherapy for downstaging the cancer should be considered. Docetaxel is a semisynthetic taxane that promotes tubulin polymerization and inhibits microtubule depolymerization. In recent studies, many metastatic gastric cancers were treated using neoadjuvant chemotherapy with docetaxel, and the response rates were reported. We report here two cases of locally advanced, non-resectable gastric cancer that were candidates for a curative resection after induction chemotherapy with docetaxel and cisplatin.

Keyword

Advanced stomach cancer; Neoadjuvant chemotherapy; Curative resection; Docetaxel

MeSH Terms

Cisplatin*
Diagnosis
Drug Therapy*
Humans
Induction Chemotherapy
Microtubules
Neoplasm Metastasis
Polymerization
Polymers
Stomach Neoplasms*
Tubulin
Cisplatin
Polymers
Tubulin