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Alyssin and Iberin in Cruciferous Vegetables Exert Anticancer Activity in HepG2 by Increasing Intracellular Reactive Oxygen Species and Tubulin Depolymerization

Pocasap P, Weerapreeyakul N, Thumanu K

To determine the chemopreventive potential of alyssin and iberin, the in vitro anticancer activities and molecular targets of isothiocyanates (ITCs) were measured and compared to sulforaphane in hepatocellular carcinoma cell...
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Proteomic Analysis on Exosomes Derived from Patients’ Sera Infected with Echinococcus granulosus

Wang W, Zhou X, Cui F, Shi C, Wang Y, Men Y, Zhao W, Zhao J

Cystic echinococcosis (CE), a zoonotic disease caused by Echinococcus granulosus at the larval stage, predominantly develops in the liver and lungs of intermediate hosts and eventually results in organ malfunction...
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Bisifusarium Delphinoides, an Emerging Opportunistic Pathogen in a Burn Patient with Diabetes Mellitus

Park JH, Oh J, Song JS, Kim J, Sung GH

An 82-year-old man with diabetes was admitted to the emergency department with a third-degree burn on his left leg. The deep swab specimen from his left leg was cultured on...
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Antitumor Effect of KX-01 through Inhibiting Src Family Kinases and Mitosis

Kim S, Min A, Lee KH, Yang Y, Kim TY, Lim JM, Park SJ, Nam HJ, Kim JE, Song SH, Han SW, Oh DY, Kim JH, Kim TY, Hangauer D, Lau JY, Im K, Lee DS, Bang YJ, Im SA

PURPOSE: KX-01 is a novel dual inhibitor of Src and tubulin. Unlike previous Src inhibitors that failed to show clinical benefit during treatment of breast cancer, KX-01 can potentially overcome...
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First Report of Anthracnose Caused by Colletotrichum fioriniae on Chinese Matrimony Vine in Korea

Oo MM, Tweneboah , Oh SK

A fungus, Colletotrichum fioriniae, was isolated for the first time from fruits of Chinese matrimony vine (Lycium chinense Mill.) in Korea. It was classified as C. fioriniae based on the...
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Serial Morphological Changes of Side-Branch Ostium after Paclitaxel-Coated Balloon Treatment of De Novo Coronary Lesions of Main Vessels

Her AY, Ann SH, Singh GB, Kim YH, Okamura T, Garg S, Koo BK, Shin ES

PURPOSE: The effects on the side-branch (SB) ostium, following paclitaxel-coated balloon (PCB) treatment of de novo coronary lesions of main vessels have not been previously investigated. This study was aimed...
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Differentiation of Human Dental Pulp Stem Cells into Dopaminergic Neuron-like Cells in Vitro

Chun SY, Soker S, Jang YJ, Kwon TG, Yoo ES

We investigated the potential of human dental pulp stem cells (hDPSCs) to differentiate into dopaminergic neurons in vitro as an autologous stem cell source for Parkinson's disease treatment. The hDPSCs...
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Viriditoxin Induces G2/M Cell Cycle Arrest and Apoptosis in A549 Human Lung Cancer Cells

Park JH, Noh TH, Wang H, Kim ND, Jung JH

Viriditoxin is a fungal metabolite isolated from Paecilomyces variotii, which was derived from the giant jellyfish Nemopilema nomurai. Viriditoxin was reported to inhibit polymerization of FtsZ, which is a key...
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Discovery of Two New Talaromyces Species from Crop Field Soil in Korea

Adhikari M, Yadav DR, Kim S, Um YH, Kim HS, Lee HB, Lee YS

Two new fungal species of the genus Talaromyces, Talaromyces purpurogenus and Talaromyces trachyspermus from the Trichocomaceae family, were recovered during an investigation of fungal communities in soil collected from the...
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Confirmation of Two Undescribed Fungal Species from Dokdo of Korea Based on Current Classification System Using Multi Loci

Lee HW, Nguyen TT, Mun HY, Lee H, Kim C, Lee HB

Using dilution plating method, 47 fungal isolates were obtained from a soil sample collected from Dokdo in the East Sea of Korea in 2013. In this study, two fungal isolates,...
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Molecular Identification and Amphotericin B Susceptibility Testing of Clinical Isolates of Aspergillus From 11 Hospitals in Korea

Heo MS, Shin JH, Choi MJ, Park YJ, Lee HS, Koo SH, Lee WG, Kim SH, Shin MG, Suh SP, Ryang DW

BACKGROUND: We investigated the species distribution and amphotericin B (AMB) susceptibility of Korean clinical Aspergillus isolates by using two Etests and the CLSI broth microdilution method. METHODS: A total of 136...
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Aspergillus Associated with Meju, a Fermented Soybean Starting Material for Traditional Soy Sauce and Soybean Paste in Korea

Hong SB, Kim DH, Samson RA

Aspergillus is an important fungal genus used for the fermentation of Asian foods; this genus is referred to as koji mold in Japan and China. A. oryzae, A. sojae, and...
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N-acetyl-D-glucosamine kinase interacts with dynein light-chain roadblock type 1 at Golgi outposts in neuronal dendritic branch points

Islam MA, Sharif SR, Lee H, Seog DH, Moon IS

N-acetylglucosamine kinase (GlcNAc kinase or NAGK) is a ubiquitously expressed enzyme in mammalian cells. Recent studies have shown that NAGK has an essential structural, non-enzymatic role in the upregulation of...
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Aspergillus clavatus Y2H0002 as a New Endophytic Fungal Strain Producing Gibberellins Isolated from Nymphoides pe ltata in Fresh Water

You YH, Kwak TW, Kang SM, Lee MC, Kim JG

Eighteen endophytic fungi with different colony morphologies were isolated from the roots of Nymphoides peltata growing in the Dalsung wetland. The fungal culture filtrates of the endophytic fungi were treated...
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Neurosphere and adherent culture conditions are equivalent for malignant glioma stem cell lines

Rahman M, Reyner K, Deleyrolle L, Millette S, Azari H, Day BW, Stringer B, Boyd AW, Johns TG, Blot V, Duggal R, Reynolds B

Certain limitations of the neurosphere assay (NSA) have resulted in a search for alternative culture techniques for brain tumor-initiating cells (TICs). Recently, reports have described growing glioblastoma (GBM) TICs as...
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Staurosporine Induces ROS-Mediated Process Formation in Human Gingival Fibroblasts and Rat Cortical Astrocytes

Lee HG, Kim DS, Moon SA, Kang JW, Seo JT

In the present study, we investigated the effect of staurosporine on the formation of cellular processes in human gingival fibroblasts and rat astrocytes. Staurosporine caused a rapid induction of process...
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Characterization and Pathogenicity of Alternaria vanuatuensis, a New Record from Allium Plants in Korea and China

Li MJ, Deng JX, Paul NC, Lee HB, Yu SH

Alternaria from different Allium plants was characterized by multilocus sequence analysis. Based on sequences of the beta-tubulin (BT2b), the Alternaria allergen a1 (Alt a1), and the RNA polymerase II second...
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A New Record of Penicillium raphiae Isolated from Agricultural Soil of Ulleung Island, Korea

Paul NC, Mun HY, Lee HW, Yu SH, Lee HB

A fungal isolate EML-NCP01 was recovered from agricultural soil in Ulleung Island, Korea. Phylogenetic analysis of internal transcribed spacer and beta-tubulin genes identified the isolate as the Penicillium species P....
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The First Report of Penicillium georgiense in Malaysia

Yee TL, Zakaria L

Penicillium georgiense was isolated from sandy beach soil from Batu Ferringhi beach, Penang Island, Malaysia. The identification was based on morphological characteristics and phylogenetic analysis of internal transcribed spacer regions...
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Neurogenic differentiation of human dental stem cells in vitro

Lee JH, Um S, Song IS, Kim HY, Seo BM

OBJECTIVES: The purpose of this study was to investigate the neurogenic differentiation of human dental pulp stem cells (DPSCs), periodontal ligament stem cells (PDLSCs), and stem cells from apical papilla...
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