J Bone Metab.  2017 Feb;24(1):51-58. 10.11005/jbm.2017.24.1.51.

Association of Serum 25-hydroxy-vitamin D Concentration and Arterial Stiffness among Korean Adults in Single Center

Affiliations
  • 1Department of Family Medicine, Gachon University Gil Medical Center, Gachon University School of Medicine, Incheon, Korea. fmeye@hanmail.net

Abstract

BACKGROUND
There are growing concerns about the role of vitamin D deficiency in cardiovascular diseases. Therefore, we investigated the correlation between serum 25-hydroxy-vitamin D (25[OH]D) and arterial stiffness among Korean adults.
METHODS
We retrospectively reviewed the medical charts of 302 people (115 women and 187 men) who visited a tertiary hospital from January 2015 to December 2016. Serum 25(OH)D was measured using the radioimmunoassay technique, and brachial-ankle pulse wave velocity (baPWV) was measured using an automatic wave analyzer. We obtained the doctor's report on the medical history of the participants, their alcohol consumption and smoking habits, and their exercise status. Metabolic syndrome was diagnosed based on guidelines from the National Cholesterol Education Program (NCEP)-Adult Treatment Panel (ATP III) and the International Diabetes Federation (IDF). Results of basic blood tests and physical assessment were also collected.
RESULTS
In the Pearson correlation analysis, serum 25(OH)D and baPWV showed a statistically significant inverse relationship (r=-0.279, P<0.001). Using multiple regression analysis, and after adjusting for possible confounders, serum 25(OH)D concentration was found to be significantly associated with baPWV (β=-0.121, P=0.011).
CONCLUSIONS
We observed an association between serum 25(OH)D concentration and arterial stiffness. Further studies involving larger sample sizes will be needed to confirm this associations.

Keyword

Adult; 25-hydroxyvitamin D3; Vascular stiffness

MeSH Terms

Adult*
Alcohol Drinking
Calcifediol
Cardiovascular Diseases
Cholesterol
Education
Female
Hematologic Tests
Humans
Pulse Wave Analysis
Radioimmunoassay
Retrospective Studies
Sample Size
Smoke
Smoking
Tertiary Care Centers
Vascular Stiffness*
Vitamin D Deficiency
Calcifediol
Cholesterol
Smoke

Figure

  • Fig. 1 Correlation between 25-hydroxy-vitamin D (25[OH]D) and brachial-ankle pulse wave velocity (baPWV), scatter diagram.


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