Electrolyte Blood Press.  2017 Dec;15(2):27-36. 10.5049/EBP.2017.15.2.27.

25-hydroxyvitamin D Levels was not Associated with Blood Pressure and Arterial Stiffness in Patients with Chronic Kidney Disease

• Park KM
• Jun HH
• Bae J
• Choi YB
• Yang DH
• Jeong HY
• Lee MJ
• Lee SY

• KMID: 2401150
• DOI: http://doi.org/10.5049/EBP.2017.15.2.27

Abstract

BACKGROUND
We investigated the effect of vitamin D deficiency on cardiovascular risk profiles in an Asian population with chronic kidney disease (CKD).
METHODS
A total of 210 participants (62 non-dialysis CKD patients and 148 hemodialysis [HD] patients) were enrolled between December 2009 and February 2010. Vitamin D deficiency was determined using the serum 25-hydroxyvitamin D [25(OH)D] concentration. Blood pressure and arterial stiffness were measured. Subjects were divided into groups according to 25(OH)D concentration based on a cut-off of 13.5 ng/mL in non-dialysis CKD patients and 11.3 ng/mL in HD patients.
RESULTS
The mean age was 61.7±12.3 years in non-dialysis CKD patients and 57.0±12.7 years in HD patients. In the non-dialysis CKD group, mean estimated glomerular filtration rate (eGFR) was 29.7±15.4 mL/min/1.73 m2. Mean 25(OH)D concentration was 13.6±7.8 ng/mL in non-dialysis CKD patients and 11.3±6.7 ng/mL in HD patients. More than half of the subjects had vitamin D deficiency (67.6% in non-dialysis CKD patients and 80.4% in HD patients). There were no significant differences in systolic blood pressure, pulse pressure, and arterial stiffness between higher and lower 25(OH)D groups among non-dialysis CKD and HD patients. Multivariate analysis revealed that female sex (odds ratio [OR]: 5.890; 95% confidence interval [CI]: 2.597-13.387; p<0.001) and presence of diabetes (OR: 2.434; 95% CI: 1.103-5.370; p=0.028) were significantly associated with lower serum 25(OH)D levels in HD patients.
CONCLUSION
The prevalence of vitamin D deficiency was high in both nondialysis CKD patients and HD patients. Serum 25(OH)D concentration was not a significant factor associated with blood pressure and arterial stiffness among non-dialysis CKD and HD patients.

Keyword

Blood pressure; Cardiovascular risk; Chronic kidney disease; 25-Hydroxyvitamin D

MeSH Terms

Asian Continental Ancestry Group
Blood Pressure*
Female
Glomerular Filtration Rate
Humans
Multivariate Analysis
Prevalence
Renal Dialysis
Renal Insufficiency, Chronic*
Vascular Stiffness*
Vitamin D Deficiency

Figure

• 

  Fig. 1 Pearson's correlation coefficient (R) and p-value (P) for 1,25-(OH)2D and 25(OH)D. (A) Scatter plot of 1,25-(OH)2D and 25(OH)D in non-dialysis CKD patients and (B) HD patients. CKD, chronic kidney disease; HD, hemodialysis.

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