Gut Liver.  2016 Sep;10(5):818-825. 10.5009/gnl15331.

Relationship between 25-Hydroxyvitamin D Levels and Liver Fibrosis as Assessed by Transient Elastography in Patients with Chronic Liver Disease

• Ko BJ
• Kim YS
• Kim SG
• Park JH
• Lee SH
• Jeong SW
• Jang JY
• Kim HS
• Kim BS
• Kim SM
• Kim YD
• Cheon GJ
• Lee BR

• KMID: 2412081
• DOI: http://doi.org/10.5009/gnl15331

Abstract

BACKGROUND/AIMS
Deficiencies of 25-hydroxyvitamin D (25(OH)D) are prevalent in patients with chronic liver disease (CLD). Liver fibrosis is the main determinant of CLD prognosis. The present study was performed to evaluate the correlation between 25(OH)D levels and liver fibrosis as assessed by transient elastography (TE) in patients with compensated CLD.
METHODS
Serum 25(OH)D levels and liver stiffness were determined in a total of 207 patients who were subjected to the following exclusion criteria: patients with decompensated CLD; patients who had malignancies; patients who were taking medications; and patients who were pregnant.
RESULTS
The most common etiology was chronic hepatitis B (53.1%). Advanced liver fibrosis (defined by TE [≥9.5 kPa]) was present in 75 patients (36.2%). There was a significant correlation between 25(OH)D deficiency and liver stiffness. Based on the multivariate analysis, the following factors were independently associated with advanced liver fibrosis: 25(OH)D deficiency (odds ratio [OR], 3.46; p=0.004), diabetes mellitus (OR, 3.04; p=0.041), and fibrosis-4 index (OR, 2.01; p<0.001).
CONCLUSIONS
Patients with compensated CLD exhibit a close correlation between vitamin D level and liver stiffness as assessed by TE. Vitamin D deficiency was independently associated with advanced liver fibrosis.

Keyword

25-Hydroxyvitamin D deficiency; Transient elastography; Liver stiffness

MeSH Terms

Adult
Chronic Disease
Elasticity Imaging Techniques/*methods
Female
Hepatitis B, Chronic/blood/complications
Humans
Liver Cirrhosis/blood/*diagnostic imaging/etiology/pathology
Liver Diseases/*blood/complications
Male
Middle Aged
Multivariate Analysis
Vitamin D/*analogs & derivatives/blood
Vitamin D Deficiency/complications
Vitamin D