Neonatal Med.  2017 Feb;24(1):1-6. 10.5385/nm.2017.24.1.1.

Bronchopulmonary Dysplasia and Ureaplasma: What Do We Know So Far?

• de la Haye N
• Hütten MC
• Kunzmann S
• Kramer BW

• KMID: 2371408
• DOI: http://doi.org/10.5385/nm.2017.24.1.1

Abstract

Bronchopulmonary dysplasia (BPD) is the most common morbidity of prematurity. BPD is a chronic respiratory disease related to lung-injury during the primary course of critical lung disease such as respiratory distress syndrome or when abnormal development of the preterm lung occurs. Abnormal lung development not only results from primary lung injury in the first days after birth, but also secondary injury through abnormal repair resulting in arrested and abnormal alveolarization, fibrosis and pulmonary vascular dysgenesis. Chorioamnionitis is a risk factor that plays an important role in the development of BPD. Ureaplasma subspecies (spp.) are the most common isolated organisms from chorioamniotic tissue after premature births. Therefore Ureaplasma spp. appear to play an important role in the development of BPD, and treatment or prophylactic treatment of these infections or colonization may reduce the incidence, morbidity and mortality of BPD. Ureaplasma spp. infections are challenging not only to treat, but also to diagnosis in a timely manner. This review summarizes the current state of treatment and new developments in the treatment of Ureaplasma exposure in premature infants.

Keyword

Bronchopulmonary dysplasia; Ureaplasma; Chorioamnionitis; ultrasonography; Solithromycin; Azithromycin

MeSH Terms

Azithromycin
Bronchopulmonary Dysplasia*
Chorioamnionitis
Colon
Diagnosis
Female
Fibrosis
Humans
Incidence
Infant, Newborn
Infant, Premature
Lung
Lung Diseases
Lung Injury
Mortality
Parturition
Pregnancy
Premature Birth
Risk Factors
Ultrasonography
Ureaplasma*
Azithromycin