Korean J Vet Res.  2016 Sep;56(3):161-166. 10.14405/kjvr.2016.56.3.161.

Cardiocirculatory, biochemical and hemostatic evaluation of dogs with hyperadrenocorticism at diagnosis and after treatment

Affiliations
  • 1School of Veterinary Medicine, Centro Universitario Ritter dos Reis-UniRitter, Porto Alegre 90840-440, Brazil. fredaecio@gmail.com
  • 2Department of Veterinary Clinical Pathology, School of Veterinary Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre 90040-060, Brazil.

Abstract

Hyperadrenocorticism (HAC) is a common endocrinopathy among dogs that causes multisystemic signs. This study was conducted to evaluate cardiocirculatory, biochemical, and hemostatic parameters in dogs with HAC at diagnosis, in addition to verifying whether abnormal parameters could be controlled by initial treatment with trilostane. Fifteen dogs with HAC were assessed by systolic blood pressure measurement, electrocardiography, Doppler echocardiography, serum concentration of troponin I, and biochemical and hemostatic profile at diagnosis and after trilostane therapy. Unlike biochemical parameters, hemostatic and cardiocirculatory parameters were not significantly influenced by the onset of treatment. The authors believe that clinical treatment with trilostane for 3 to 4 months might not be sufficient for the stabilization of cardiocirculatory abnormalities such as hypertension. Therefore, dogs with HAC must receive cardiocirculatory monitoring at diagnosis and during drug treatment.

Keyword

canine; cardiac troponin I; cardiology; endocrinology; trilostane

MeSH Terms

Adrenocortical Hyperfunction*
Animals
Blood Pressure
Cardiology
Diagnosis*
Dogs*
Echocardiography, Doppler
Electrocardiography
Endocrinology
Hypertension
Troponin I
Troponin I
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