J Vet Sci.  2005 Dec;6(4):363-366.

A case of adrenal gland dependent hyperadrenocorticism with mitotane therapy in a Yorkshire terrier dog

• Lee YM
• Kang BT
• Jung DI
• Park C
• Kim HJ
• Kim JW
• Lim CY
• Park EH
• Park HM

Abstract

Hyperadrenocorticism, a disorder characterized by excessive production of cortisol by the adrenal cortex, is wellrecognized in dogs. A 10-year-old, intact male, Yorkshire terrier dog was evaluated because of corneal ulceration and generalized alopecia. Diagnosis was made based on history taking, clinical signs, physical examination, and results of routine laboratory testing (complete blood count, serum biochemical analysis, and urinalysis). In addition, adrenocorticotropic hormone (ACTH) stimulation test and abdominal ultrasonography were also used to diagnose this case. The patient was diagnosed as adrenal gland neoplasia and medical therapy using the adrenocorticolytic agent, mitotane, was initiated. An ACTH stimulation test was performed after initial therapy. After successful induction was obtained, maintenance therapy with mitotane still continued.

Keyword

adrenal gland tumor; dog; hyperadrenocorticism

MeSH Terms

Adrenal Gland Neoplasms/complications/diagnosis/drug therapy/*veterinary
Adrenocortical Hyperfunction/diagnosis/drug therapy/etiology/*veterinary
Adrenocorticotropic Hormone/blood
Animals
Antineoplastic Agents, Hormonal/*therapeutic use
Dog Diseases/*drug therapy
Dogs
Male
Mitotane/*therapeutic use
Radiography, Abdominal/veterinary
Tomography, X-Ray/veterinary