Korean J Vet Res.
2016 Jun;56(2):117-120. 10.14405/kjvr.2016.56.2.117.
Appearance of osteoporosis in rat experimental autoimmune encephalomyelitis
- Affiliations
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- 1School of Medicine, College of Veterinary Medicine, Jeju National University, Jeju 63243, Korea. healthy@jejunu.ac.kr
- 2Department of Veterinary Anatomy, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Korea.
- 3Department of Veterinary Anatomy, College of Veterinary Medicine, Jeju National University, Jeju 63243, Korea. shint@jejunu.ac.kr
- 4Department of Molecular Anatomy, School of Medicine, University of the Ryukyus, Uehara, Nishihara, Okinawa 9030215, Japan.
- 5Korea Research Institute of Bioscience and Biotechnology, Korea Research Institute of Bioscience and Biotechnology, Jeongeup 56212, Korea.
- 6Department of Anatomy, School of Medicine, Wonkwang University, Iksan 54538, Korea.
- KMID: 2368754
- DOI: http://doi.org/10.14405/kjvr.2016.56.2.117
Abstract
- Experimental autoimmune encephalomyelitis (EAE) in Lewis rats is characterized by transient paralysis followed by recovery. To evaluate whether transient paralysis in EAE affects bone density, tibiae of EAE rats were morphologically investigated using micro-computed tomography and histology. The parameters of bone health were significantly reduced at the peak stage of EAE rats relative to those of controls (p < 0.05). The reduction of bone density was found to remain unchanged, even in the recovery stage. Collectively, the present data suggest that osteoporosis occurs in paralytic rats with monophasic EAE, possibly through the disuse of hindlimbs and/or autoimmune inflammation.
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