Ann Clin Neurophysiol.  2017 Jan;19(1):74-76. 10.14253/acn.2017.19.1.74.

Muscle-specific receptor tyrosine kinase (MuSK) myasthenia gravis associated with castleman disease

• Oh J
• Yang WI
• Cho JH
• Sunwoo IN

• KMID: 2368001
• DOI: http://doi.org/10.14253/acn.2017.19.1.74

Abstract

Muscle specific tyrosine kinase (MuSK) myasthenia gravis (MG) is a rare subtype of MG, which is immunologically distinct and differential therapeutic response. Though MG is often associated with other autoimmune disorders or malignancy, concurrence of other disease and MuSK MG has been infrequently reported. We present a patient of MuSK MG associated with multicentric Castelman disease.

Keyword

Castleman disease; Myasthenia gravis; Muscle specific tyrosine kinase

MeSH Terms

Giant Lymph Node Hyperplasia*
Humans
Myasthenia Gravis*
Protein-Tyrosine Kinases*
Tyrosine*
Protein-Tyrosine Kinases
Tyrosine

Figure

• 

  Fig. 1. Cervical lymph node biopsy demonstrates (A) lymphoid follicle hyperplasia with interfollicular sheets of plasma cells (hematoxylin and eosin statin; original magnification ×100) (B) which are positive in CD138 (immunohistochemical stain for CD138; original magnification ×200).

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