J Neurogastroenterol Motil.  2017 Jan;23(1):109-116. 10.5056/jnm16003.

Effect of DA-9701, a Novel Prokinetic Agent, on Post-operative Ileus in Rats

• Lee SP
• Lee OY
• Lee KN
• Lee HL
• Choi HS
• Yoon BC
• Jun DW

• KMID: 2367462
• DOI: http://doi.org/10.5056/jnm16003

Abstract

BACKGROUND/AIMS
Post-operative ileus (POI) is a common complication of abdominal surgery. DA-9701, an extract of Pharbitis Semen and Corydalis Tuber, is a new prokinetic agent that also alleviates visceral pain. The aim of this study was to investigate whether DA-9701 can ameliorate POI in rats.
METHODS
A total of 32 rats were divided into 4 groups: no surgery/no medication (NSNM), no surgery/medication (NSM), surgery/no medication (SNM), and surgery/medication (SM). Gastrointestinal transit (GIT), which is assessed by migration of charcoal, and cumulative stool weight were measured at 24 hours after surgery.
RESULTS
GIT was significantly more delayed in the SNM group than in the other groups (SNM vs NSNM, P < 0.001; SNM vs NSM, P < 0.001; SNM vs SM, P = 0.005). Cumulative stool weight in that group was also lower than in the no surgery groups (SNM vs NSNM, P = 0.007; SNM vs NSM, P = 0.033), and there was no significant difference between the SM group and the no surgery groups (SM vs NSM, P = 0.703; SM vs NSNM, P = 0.347).
CONCLUSION
DA-9701 can ameliorate POI by reducing delayed GIT and improving defecation in a rat model of POI.

Keyword

Corydalis; DA-9701; Gastrointestinal transit; Ghrelin; Ileus

MeSH Terms

Animals
Charcoal
Corydalis
Defecation
Gastrointestinal Transit
Ghrelin
Ileus*
Models, Animal
Rats*
Semen
Visceral Pain
Charcoal
Ghrelin