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Effect of DA-9701, a Novel Prokinetic Agent, on Post-operative Ileus in Rats

Lee SP, Lee OY, Lee KN, Lee HL, Choi HS, Yoon BC, Jun DW

  • KMID: 2367462
  • J Neurogastroenterol Motil.
  • 2017 Jan;23(1):109-116.
  • doi: 10.5056/jnm16003
BACKGROUND/AIMS: Post-operative ileus (POI) is a common complication of abdominal surgery. DA-9701, an extract of Pharbitis Semen and Corydalis Tuber, is a new prokinetic agent that also alleviates visceral pain....
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The Effect of DA-9701 in Opioid-induced Bowel Dysfunction of Guinea Pig

Hussain Z, Rhee KW, Lee YJ, Park H

  • KMID: 2327959
  • J Neurogastroenterol Motil.
  • 2016 Jul;22(3):529-538.
  • doi: 10.5056/jnm15194
BACKGROUND/AIMS: Opioid induced bowel dysfunction (OIBD) is associated with decreased gastrointestinal (GI) propulsive activity due to intake of opioid analgesics. DA-9701, a novel prokinetic agent formulated with Pharbitis Semen and...
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Aldose Reductase Inhibitory Alkaloids from Corydalis ternata

Seo W, Jung SH, Shim SH

A methanolic extract of Corydalis ternata having aldose reductase inhibitory activity was examined as a possible aldose reductase (ALR2) inhibitor, a key enzyme involved in diabetic complications. Seven alkaloids, tetrahydrocoptisine...
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Randomized, Controlled, Multi-center Trial: Comparing the Safety and Efficacy of DA-9701 and Itopride Hydrochloride in Patients With Functional Dyspepsia

Choi MG, Rhee PL, Park H, Lee OY, Lee KJ, Choi SC, Seol SY, Chun HJ, Rew JS, Lee DH, Song GA, Jung HY, Jeong HY, Sung IK, Lee JS, Lee ST, Kim SK, Shin YW

  • KMID: 2433481
  • J Neurogastroenterol Motil.
  • 2015 Jul;21(3):414-422.
  • doi: 10.5056/jnm14117
BACKGROUND/AIMS: Therapies of functional dyspepsia (FD) are limited. DA-9701 is a novel prokinetic agent formulated with Pharbitis semen and Corydalis Tuber. We aimed to assess the efficacy of DA-9701 compared...
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Effects of the New Prokinetic Agent DA-9701 Formulated With Corydalis Tuber and Pharbitis Seed in Patients With Minimal Change Esophagitis: A Bicenter, Randomized, Double Blind, Placebo-controlled Study

Park CH, Kim HS, Lee SK

  • KMID: 2381192
  • J Neurogastroenterol Motil.
  • 2014 Jul;20(3):338-346.
BACKGROUND/AIMS: DA-9701 (Motilitone) is a new prokinetic agent formulated with Corydalis Tuber and Pharbitis Seed. We assessed the efficacy of DA-9701 in symptomatic patients with minimal change esophagitis. METHODS: Patients with...
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DA-9701: A New Multi-Acting Drug for the Treatment of Functional Dyspepsia

Kwon YS, Son M

  • KMID: 1502485
  • Biomol Ther.
  • 2013 May;21(3):181-189.
Motilitone(R) (DA-9701) is a new herbal drug that was launched for the treatment of functional dyspepsia in December 2011 in Korea. The heterogeneous symptom pattern and multiple causes of functional...
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Antinociceptive Effect of Cyperi rhizoma and Corydalis tuber Extracts on Neuropathic Pain in Rats

Choi JG, Kang SY, Kim JM, Roh DH, Yoon SY, Park JB, Lee JH, Kim HW

In this study, we examined the antinociceptive effect of Cyperi rhizoma (CR) and Corydalis tuber (CT) extracts using a chronic constriction injury-induced neuropathic pain rat model. After the ligation of...
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Effects of Herbal Bath "HAC" on Functional Recovery and c-Fos Expression in the Ventrolateral Periaqueductal Gray Region after Sciatic Crushed Nerve Injury in Rats

Ryu MS, Lim HH, Song YK, Lee HJ, Seo JH, Lee MH, Shin MS, Kim CJ

Peripheral nerve injuries are a commonly encountered clinical problem and often result in a chronic pain and severe functional deficits. c-Fos expression is sometimes used as a marker of increased...
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A case of acute cholestatic hepatitis induced by Corydalis speciosa Max

Kang HS, Choi HS, Yun TJ, Lee KG, Seo YS, Yeon JE, Byun KS, Um SH, Kim CD, Ryu HS

Herbs are widely used as treatments for various symptoms. However, several herbs have been reported to be inducers of liver injury. We report herein a case of hepatotoxicity induced by...
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Effect of 1-corydalmine,an Alkaloid Isolated from Corydalis chaerophylla Roots on Spore Germination of Some Fungi

Basha SA, Jha RN, Pandey VB, Singh UP

  • KMID: 2383709
  • Mycobiology.
  • 2007 Jun;35(2):69-71.
1-Corydalmine,an alkaloid isolated from roots of Corydalis chaerophylla inhibited spore germination of some plant pathogenic as well as saprophytic fungi e.g. Alternaria brassicae, A. brassicicola, A. solani, Curvularia lunata, C....
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Antifungal Activity of Narceine Methyl Ester and Narceine Isolated from Corydalis longipes Against Some Phytopathogenic Fungi

Chowdhury , Maurya S, Pandey MB, Pandey VB, Sarma BK, Singh UP

  • KMID: 2312470
  • Mycobiology.
  • 2005 Dec;33(4):206-209.
Narceine methyl ester and narceine are potent alkaloids which were isolated from Corydalis longipes were found effective in vitro at very low concentration, i.e., 100~500 ppm against spore germination of...
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Regulation of glutamate level in rat brain through activation of glutamate dehydrogenase by Corydalis ternata

Lee KH, Huh JW, Choi MM, Yoon SY, Yang SJ, Hong HN, Cho SW

  • KMID: 1093472
  • Exp Mol Med.
  • 2005 Aug;37(4):371-377.
When treated with protopine and alkalized extracts of the tuber of Corydalis ternata for one year, significant decrease in glutamate level and increase in glutamate dehydrogenase (GDH) activity was observed...
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Inhibitory Effect of Two Alkaloids, (-)-Corydalmine and (-)-Isocorypalmine Isolated from Corydalis chaerophylla on Several Phytopathogenic Fungi

Sahni S, Maurya S, Jha RN, Pandey VB, Singh UP

  • KMID: 2312442
  • Mycobiology.
  • 2004 Dec;32(4):160-163.
Medicinal plants play important roles in controlling plant diseases as one of the safest and ecofriendly methods. These plants have been used in the form of crude extracts as well...
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Effect of the Mixture of Two Plant Alkaloids Isolated from Corydalis longipes Against Balsam Powdery Mildew on Detached Leaves and Pea Powdery Mildew in Field

Gohain L, Maurya S, Pandey MB, Pandey VB, Singh UP

  • KMID: 2312441
  • Mycobiology.
  • 2004 Dec;32(4):155-159.
N-Methylhydrasteine hydroxylactam and 1-methoxyberberine chloride, both alkaloids, extracted from Corydalis longipes have been assayed for their activities against two powdery mildews. The spore germination of Erysiphe cichoracearum on detached leaf...
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Antifungal Activity of Chaerophylline and Berberine Hydroxide Isolated from Corydalis Species

Tuli L, Jha RN, Pandey VB, Singh UP

  • KMID: 1993710
  • Mycobiology.
  • 2001 Jun;29(2):100-103.
Chaerophylline and berberine hydroxide, both being alkaloids, isolated from Corydalis chaerophylla and C. longipes respectively were assayed against spore germination of some fungi, e.g. Alternaria solani, A. brassicola, A. brassicicola,...
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