J Bacteriol Virol.  2016 Dec;46(4):312-318. 10.4167/jbv.2016.46.4.312.

Apoptotic Effect of Macrophages against Mycobacterium tuberculosis

• Kim LH
• Shin SJ

• KMID: 2366879
• DOI: http://doi.org/10.4167/jbv.2016.46.4.312

Abstract

Mycobacterium tuberculosis (Mtb) causing tuberculosis as an intracellular pathogen initially infects alveolar macrophages following aerosol inhalation. Thus, macrophages play a critical role in the establishment of Mtb infection and macrophage cell death, a common outcome during Mtb infection, may initiate host- or pathogen-favored immune responses, resulting in facilitating protection or pathogenesis, respectively. In addition, virulent Mtb strains are known to inhibit apoptosis and consequently down-regulates immune response using a variety of strategies. In many recent studies have shown that virulent Mtb can either augment or reduce apoptosis by regulating expression of pro-apoptotic and anti-apoptotic proteins belonging to Bcl-2 family proteins. In this review, we will discuss and dissect the apoptotic pathways of Bcl-2 family proteins in Mtb-infected macrophages.

Keyword

Mycobacterium tuberculosis; Apoptosis; Bcl-2 family proteins; Anti-apoptotic proteins; Pro-apoptotic proteins

MeSH Terms

Apoptosis
Apoptosis Regulatory Proteins
Cell Death
Humans
Inhalation
Macrophages*
Macrophages, Alveolar
Mycobacterium tuberculosis*
Mycobacterium*
Tuberculosis
Apoptosis Regulatory Proteins

Figure

• 

  Figure 1. Regulation of apoptosis signaling pathway by Bcl-2 family proteins. The mitochondrial outer membrane permeabilization (MOMP) can be regulated by either extrinsic (death receptor-mediated) and intrinsic (mitochondria-mediated) pathways. MOMP triggers the release of apoptogenic factor such as cytochrome c into cytosol to facilitate activation of caspase 3, resulting in induction of apoptosis. Virulent Mtb promotes the induction and production of Bcl-2 family proteins (①) and eventually inhibits apoptosis pathways (②) to multiplicate inside macrophages. FADD; Fas-associated death domain, Bax; Bcl-2-associated X protein, Bak; Bcl-2-antagonist killer, (t)Bid;(truncated) Bax-like BH3 protein, DISC; Death inducing signaling complex, Apaf1; Apoptotic protease activating factor 1, Mtb; Mycobacterium tuberculosis

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