Ann Pediatr Endocrinol Metab.  2016 Sep;21(3):143-148. 10.6065/apem.2016.21.3.143.

The cutoff values of indirect indices for measuring insulin resistance for metabolic syndrome in Korean children and adolescents

• Kim JW
• Park SH
• Kim Y
• Im M
• Han HS

• KMID: 2366789
• DOI: http://doi.org/10.6065/apem.2016.21.3.143

Abstract

PURPOSE
The prevalence rates of metabolic syndrome (MetS) and percentile distribution of insulin resistance (IR) among Korean children and adolescents were investigated. The cutoff values of IR were calculated to identify high-risk MetS groups.
METHODS
Data from 3,313 Korean subjects (1,756 boys and 1,557 girls, aged 10-18 years) were included from the Korean National Health and Nutrition Examination Survey conducted during 2007-2010. Three different sets of criteria for MetS were used. Indirect measures of IR were homeostasis model assessment (HOMA-IR) and triglyceride and glucose (TyG) index. The cutoff values of the HOMA-IR and TyG index were obtained from the receiver operation characteristic curves.
RESULTS
According to the MetS criteria of de Ferranti el al., Cook et al., and the International Diabetes Federation, the prevalence rates in males and females were 13.9% and 12.3%, 4.6% and 3.6%, and 1.4% and 1.8%, respectively. Uses these 3 criteria, the cutoff values of the HOMA-IR and TyG index were 2.94 and 8.41, 3.29 and 8.38, and 3.54 and 8.66, respectively. The cutoff values using each of the 3 criteria approximately corresponds to the 50th-75th, 75th, and 75th-90th percentiles of normal HOMA-IR and TyG index levels.
CONCLUSION
This study describes the prevalence rates of MetS in Korean children and adolescents, an index of IR, and the cutoff values for MetS with the aim of detecting high-risk groups. The usefulness of these criteria needs to be verified by further evaluation.

Keyword

Metabolic syndrome; Insulin resistance; Adolescent; Korea

MeSH Terms

Adolescent*
Child*
Female
Glucose
Homeostasis
Humans
Insulin Resistance*
Insulin*
Korea
Male
Nutrition Surveys
Prevalence
Triglycerides
Glucose
Insulin