Ultrasonography.  2017 Jan;36(1):10-16. 10.14366/usg.16014.

Focal lesion at the midline of the prostate on transrectal ultrasonography: take it or leave it?

• Kim J
• Hwang SI
• Lee HJ
• Hong SK
• Byun SS
• Lee S
• Choe G

• KMID: 2365571
• DOI: http://doi.org/10.14366/usg.16014

Abstract

PURPOSE
The purpose of this study was to analyze the detection rate of prostate cancers from targeted biopsy specimens of midline focal lesions and to investigate the ultrasonographic findings to reduce unnecessary additional targeted biopsies.
METHODS
Ninety-eight men with midline focal lesions detected on transrectal ultrasonography were enrolled. Additional targeted biopsies for midline focal lesions were performed after 12-core random systematic biopsies. Correlations between the ultrasonographic characteristics of midline focal lesions and the pathologic results were analyzed.
RESULTS
Twenty of 98 targeted biopsy cores (20.4%) were positive for malignancy. In a univariate analysis, midline focal lesions without bulging contours (P=0.023), with involved margins (P=0.001), without hypoechoic perilesional rims (P=0.005), and with longer diameters (P=0.005) were statistically significant for cancer detection. In a multivariate analysis, involved margin (P=0.027), having longer diameter (P=0.011) or absence of hypoechoic perilesional rim (P=0.025) made a statistically significant contribution to cancer detection.
CONCLUSION
Biopsy of midline focal lesions was not always non-significant in the detection of prostate cancer. Additional targeted biopsies should be considered in cases of midline focal lesions with involved margins but without hypoechoic perilesional rims.

Keyword

Prostatic neoplasms; Ultrasonography; Image-guided biopsy

MeSH Terms

Biopsy
Humans
Image-Guided Biopsy
Male
Multivariate Analysis
Prostate*
Prostatic Neoplasms
Ultrasonography*