Allergy.  1995 Mar;15(1):85-89.

Newly sensitization to house dust mite in an isocyanate-induced asthmatic patient

• Park HS

Abstract

Isocyanate-induced asthma is known to be the most commonly found occupational asthma in our country. House dust mite is the most significant inhalant allergen in our environment. Here we report a case of occupational asthma caused by isocyanate who is newly sensitized to house dust mite after three years. he was diagnosed as having an isocyanate-induced asthma in July, 1991. He was non-atopic and had worked as a spray-painter in a funiture factory. As he left his workplace and was treated with anti-asthmatic medications, his asthmatic symptoms and airway hyperresponsiveness were much improved in the following methacholine bronchial challenge test with 5 steps-up(from 0.075 to 2.5 mg/ml) until May, 1993. For several months before the second admission (October, 1994), his asthmatic symptoms were further aggravated and airway hyperresponsiveness to methacholine was decreased again to 0.31 mg/ml. Second skin prick test revealed a positive response to Dermatop-hagoides(D) pteronyssinus and some mold allergens. Bronchoprovocation test with D. pteronyssinus extracts demonstrated an isolated late asthmatic response. Theses results suggest that the possibility of new bronchial sensitization to inhalant allergens should be considered if asthmatic symptoms are aggravated in an occupational asthma patient with no definite cause.

MeSH Terms

Allergens
Asthma
Asthma, Occupational
Bronchial Provocation Tests
Dust*
Fungi
Humans
Methacholine Chloride
Pyroglyphidae*
Skin
Allergens
Dust
Methacholine Chloride