Psychiatry Investig.  2017 Jan;14(1):100-106. 10.4306/pi.2017.14.1.100.

Design and Methods of the Mood Disorder Cohort Research Consortium (MDCRC) Study

• Cho CH
• Ahn YM
• Kim SJ
• Ha TH
• Jeon HJ
• Cha B
• Moon E
• Park DY
• Baek JH
• Kang HJ
• Ryu V
• An H
• Lee HJ

• KMID: 2365019
• DOI: http://doi.org/10.4306/pi.2017.14.1.100

Abstract

The Mood Disorder Cohort Research Consortium (MDCRC) study is designed as a naturalistic observational prospective cohort study for early-onset mood disorders (major depressive disorders, bipolar disorders type 1 and 2) in South Korea. The study subjects consist of two populations: 1) patients with mood disorders under 25 years old and 2) patients with mood disorders within 2 years of treatment under 35 years old. After successful screening, the subjects are evaluated using baseline assessments and serial follow-up assessments at 3-month intervals. Between the follow-up assessments, subjects are dictated to check their own daily mood status before bedtime using the eMood chart application or a paper mood diary. At the regular visits every 3 months, inter-visit assessments are evaluated based on daily mood charts and interviews with patients. In addition to the daily mood chart, sleep quality, inter-visit major and minor mood episodes, stressful life events, and medical usage pattern with medical expenses are also assessed. Genomic DNA from blood is obtained for genomic analyses. From the MDCRC study, the clinical course, prognosis, and related factors of early-onset mood disorders can be clarified. The MDCRC is also able to facilitate translational research for mood disorders and provide a resource for the convergence study of mood disorders.

Keyword

Cohort study; Early mood disorders; Bipolar disorder; Major depressive disorder; MDCRC

MeSH Terms

Bipolar Disorder
Cohort Studies*
Depressive Disorder
Depressive Disorder, Major
DNA
Follow-Up Studies
Humans
Korea
Mass Screening
Methods*
Mood Disorders*
Prognosis
Prospective Studies
Translational Medical Research
DNA