Psychiatry Investig.
2016 May;13(3):265-276. 10.4306/pi.2016.13.3.265.
Review of Cohort Studies for Mood Disorders
- Affiliations
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- 1Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
- 2Department of Health Sciences & Technology, Department of Clinical Research Design and Evaluation, and Department of Medical Device Management and Research, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Seoul, Republic of Korea.
- 3Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
- 4Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
- 5Department of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
- 6Department of Psychiatry, Seoul National University Bundang Hospital, College of Medicine, Seoul National University, Seoul, Republic of Korea.
- 7Department of Psychiatry, Gyeongsang National University College of Medicine, Jinju, Republic of Korea.
- 8Department of Psychiatry, Pusan National University School of Medicine, Busan, Republic of Korea.
- 9Department of Psychiatry, Chonnam National University College of Medicine, Gwangju, Republic of Korea.
- 10Department of Psychiatry, Seoul National Hospital, Seoul, Republic of Korea.
- 11Department of Psychiatry, Korea University College of Medicine, Seoul, Republic of Korea. leehjeong@korea.ac.kr
- KMID: 2316643
- DOI: http://doi.org/10.4306/pi.2016.13.3.265
Abstract
- This paper aimed to review currently available cohort studies of subjects with mood disorders such as major depressive disorder (MDD) and bipolar disorder (BD). Using the PubMed and KoreaMed databases, we reviewed eight major cohort studies. Most studies recruited participants with MDD and BD separately, so direct comparison of factors associated with diagnostic changes was difficult. Regular and frequent follow-up evaluations utilizing objective mood ratings and standardized evaluation methods in a naturalistic fashion are necessary to determine detailed clinical courses of mood disorders. Further, biological samples should also be collected to incorporate clinical findings in the development of new diagnostic and therapeutic approaches. An innovative cohort study that can serve as a platform for translational research for treatment and prevention of mood disorders is critical in determining clinical, psychosocial, neurobiological and genetic factors associated with long-term courses and consequences of mood disorders in Korean patients.
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