J Clin Neurol.  2017 Jan;13(1):62-70. 10.3988/jcn.2017.13.1.62.

SCN1A Gene Mutation and Adaptive Functioning in 18 Vietnamese Children with Dravet Syndrome

• Do TT
• Vu DM
• Huynh TT
• Le TK
• Sohn EH
• Le TM
• Ha HH
• Bui CB

• KMID: 2364899
• DOI: http://doi.org/10.3988/jcn.2017.13.1.62

Abstract

BACKGROUND AND PURPOSE
Dravet syndrome is a rare and severe type of epilepsy in infants. The heterogeneity in the overall intellectual disability that these patients suffer from has been attributed to differences in genetic background and epilepsy severity.
METHODS
Eighteen Vietnamese children diagnosed with Dravet syndrome were included in this study. SCN1A variants were screened by direct sequencing and multiplex ligation-dependent probe amplification. Adaptive functioning was assessed in all patients using the Vietnamese version of the Vineland Adaptive Behavior Scales, and the results were analyzed relative to the SCN1A variants and epilepsy severity.
RESULTS
We identified 13 pathogenic or likely pathogenic variants, including 6 that have not been reported previously. We found no correlations between the presence or type of SCN1A variants and the level of adaptive functioning impairment or severity of epilepsy. Only two of nine patients aged at least 5 years had an adaptive functioning score higher than 50. Both of these patients had a low frequency of convulsive seizures and no history of status epilepticus or prolonged seizures. The remaining seven had very low adaptive functioning scores (39 or less) despite the variability in the severity of their epilepsy confirming the involvement of factors other than the severity of epilepsy in determining the developmental outcome.
CONCLUSIONS
Our study expands the spectrum of known SCN1A variants and confirms the current understanding of the role of the genetic background and epilepsy severity in determining the developmental outcome of Dravet syndrome patients.

Keyword

dravet syndrome; Vietnamese; adaptive functioning; SCN1A

MeSH Terms

Adaptation, Psychological
Asian Continental Ancestry Group*
Child*
Epilepsies, Myoclonic*
Epilepsy
Genetic Background
Humans
Infant
Intellectual Disability
Multiplex Polymerase Chain Reaction
Population Characteristics
Seizures
Status Epilepticus
Weights and Measures

Figure

• 

  Fig. 1 Adaptive functioning as assessed using the Vietnamese version of the Vineland Adaptive Behavior Scales (VVABS) in all 18 included patients during their last visit.

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