Int Neurourol J.
2016 Nov;20(Suppl 2):S84-S94. 10.5213/inj.1632752.376.
Genetic and Epigenetic Alterations in Bladder Cancer
- Affiliations
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- 1Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. gliang@usc.edu
- 2Department of Biochemistry and Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
- 3Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
- KMID: 2362501
- DOI: http://doi.org/10.5213/inj.1632752.376
Abstract
- Bladder cancer is one of the most common cancers worldwide, with a high rate of recurrence and poor outcomes as a result of relapse. Bladder cancer patients require lifelong invasive monitoring and treatment, making bladder cancer one of the most expensive malignancies. Lines of evidence increasingly point to distinct genetic and epigenetic alteration patterns in bladder cancer, even between the different stages and grades of disease. In addition, genetic and epigenetic alterations have been demonstrated to play important roles during bladder tumorigenesis. This review will focus on bladder cancer-associated genomic and epigenomic alterations, which are common in bladder cancer and provide potential diagnostic markers and therapeutic targets for bladder cancer treatment.
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