Ann Dermatol.  1989 Jan;1(1):59-63. 10.5021/ad.1989.1.1.59.

Adverse Reaction to Methotrexate and Etretinate in a Patient with Psoriasis

• Lim ES
• Kim MN
• Ro BI
• Chang CY

• KMID: 2362463
• DOI: http://doi.org/10.5021/ad.1989.1.1.59

Abstract

A 49-year-old Caucasian male patient suffered from fever general weakness and diffuse hair loss on the scalp for 3 days. Skin lesions showed erythematous scaly patches with pustules and erosions on the lower extremities and perianal region, and multiple ulcerations on the labial mucoas. A complete blood cell count revealed thrombocytopenia and leukopenia, which gradually worsened day after day (platelet: 29, 000/mm², WBC: 1,000/mm³). Candida albicans was isolated from the lesions of the oral cavity and lower extremities. Twelve days prior to the visit, he had taken etretinate Tegison®) P.O.25mg/day, prednisolone P.O. 50mg1dy and methotrexate P.O. 15mg/day for 5 days for the treatment of psoriasis. We presume that these adverse reactions may be synergistic adverse reactions, probably due to methotrexate and etretinate in consideration of the patient's history.

Keyword

Adverse reaction; Etretinate; Methotrexate; Psoriasis

MeSH Terms

Acitretin*
Blood Cell Count
Candida albicans
Etretinate*
Fever
Hair
Humans
Leukopenia
Lower Extremity
Male
Methotrexate*
Middle Aged
Mouth
Prednisolone
Psoriasis*
Scalp
Skin
Thrombocytopenia
Ulcer
Acitretin
Etretinate
Methotrexate
Prednisolone