Korean J Pediatr.  2016 Nov;59(Suppl 1):S60-S63. 10.3345/kjp.2016.59.11.S60.

A 2-month-old boy with hemolytic anemia and reticulocytopenia following intravenous immunoglobulin therapy for Kawasaki disease: a case report and literature review

Affiliations
  • 1Department of Pediatrics, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
  • 2Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, Korea.
  • 3Department of Pediatrics, CHA Gangnam Medical Center, CHA University, Seoul, Korea. epirubicin13@gmail.com
  • 4Department of Laboratory Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea.

Abstract

Herein, we report a rare case of hemolytic anemia with reticulocytopenia following intravenous immunoglobulin therapy in a young infant treated for Kawasaki disease. A 2-month-old boy presented with fever lasting 3 days, conjunctival injection, strawberry tongue, erythematous edema of the hands, and macular rash, symptoms and signs suggestive of incomplete Kawasaki disease. His fever resolved 8 days after treatment with aspirin and high dose infusion of intravenous immunoglobulin. The hemoglobin and hematocrit decreased from 9.7 g/dL and 27.1% to 7.4 g/dL and 21.3%, respectively. The patient had normocytic hypochromic anemia with anisocytosis, poikilocytosis, immature neutrophils, and nucleated red blood cells. The direct antiglobulin test result was positive, and the reticulocyte count was 1.39%. The patient had an uneventful recovery. However, reticulocytopenia persisted 1 month after discharge.

Keyword

Anemia; Hemolysis; Kawasaki disease; Reticulocytes

MeSH Terms

Anemia
Anemia, Hemolytic*
Anemia, Hypochromic
Aspirin
Coombs Test
Edema
Erythrocytes
Exanthema
Fever
Fragaria
Hand
Hematocrit
Hemolysis
Humans
Immunization, Passive*
Immunoglobulins*
Infant*
Male*
Mucocutaneous Lymph Node Syndrome*
Neutrophils
Reticulocyte Count
Reticulocytes
Tongue
Aspirin
Immunoglobulins
Full Text Links
  • KJP
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr