Korean J Blood Transfus.  2009 Apr;20(1):61-65.

A Case of Autoimmune Hemolytic Anemia Caused by Anti-e Antibody

• Kim YJ
• Kim SW
• Han TH

Abstract

The incidence of autoimmune hemolytic anemia in children is rarer than that in adults. It is estimated that the rate of autoimmune hemolytic anemia is around 2 persons per 10,000,000. We describe here a boy with warm autoimmune hemolytic anemia that was due to immunoglobulin G with an anti-e specificity. A 13-month-old boy with severe hemolytic anemia (hemoglobin: 6.0 g/dL) showed strong anti-IgG reactivity (4+) on the direct antiglobulin test. Antibody targeted against the e antigen was identified from both of his serum and the RBC eluate. In addition, he had e antigen on his RBCs. He was treated with prednisolone for 4 days and RBCs transfusions. After the second transfusion of RhD positive/e negative RBCs, his hemoglobin-level was increased to 10.3 g/dL. On his fifth hospital day, he was discharged with showing clinical improvement and improved values on his laboratory tests.

Keyword

Autoimmune hemolytic anemia; Anti-e; Immunoglobulin G

MeSH Terms

Adult
Anemia, Hemolytic
Anemia, Hemolytic, Autoimmune
Antibodies, Anti-Idiotypic
Child
Coombs Test
Humans
Immunoglobulin G
Incidence
Infant
Prednisolone
Sensitivity and Specificity
Antibodies, Anti-Idiotypic
Immunoglobulin G
Prednisolone