Exp Mol Med.
2016 Jun;48(6):e240. 10.1038/emm.2016.39.
Regulation of retinal angiogenesis by phospholipase C-β3 signaling pathway
- Affiliations
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- 1Department of Pharmacology, Gene and Cell Therapy Center for Vessel-Associated Disease, Medical Research Institute, Pusan National University School of Medicine, Yangsan, Republic of Korea. sunsik@pusan.ac.kr
- 2Department of Anesthesia and Pain Medicine, Pusan National University Hospital, Yangsan, Republic of Korea.
- 3Department of Physics, Dong-A University, Busan, Republic of Korea.
- 4Department of Anatomy, Pusan National University of Korean Medicine, Yangsan, Republic of Korea.
- 5Department of Obstetrics and Gynecology, Pusan National University Hospital, Yangsan, Republic of Korea.
- 6Department of Internal Medicine, Pusan National University Hospital, Busan, Republic of Korea.
- KMID: 2361527
- DOI: http://doi.org/10.1038/emm.2016.39
Abstract
- Angiogenesis has an essential role in many pathophysiologies. Here, we show that phospholipase C-β3 (PLC-β3) isoform regulates endothelial cell function and retinal angiogenesis. Silencing of PLC-β3 in human umbilical vein endothelial cells (HUVECs) significantly delayed proliferation, migration and capillary-like tube formation. In addition, mice lacking PLC-β3 showed impaired retinal angiogenesis with delayed endothelial proliferation, reduced endothelial cell activation, abnormal vessel formation and hemorrhage. Finally, tumor formation was significantly reduced in mice lacking PLC-β3 and showed irregular size and shape of blood vessels. These results suggest that regulation of endothelial function by PLC-β3 may contribute to angiogenesis.
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