J Rhinol.  2016 Nov;23(2):91-96. 10.18787/jr.2016.23.2.91.

Der p 1, Der p 2 and Der p 10 IgE Reactivities in Allergic Rhinitis Patients in Korea

• Choi KY
• Kim DY

• KMID: 2361321
• DOI: http://doi.org/10.18787/jr.2016.23.2.91

Abstract

BACKGROUND AND OBJECTIVES
To evaluate IgE reactivity profiles to Der p 1, Der p 2, and Der p 10 in house dust mite (HDM) allergic rhinitis (AR) patients in Korea. Symptomatic and serologic changes after sublingual immunotherapy (SLIT) were analyzed according to IgE profiles.
MATERIALS AND METHODS
Sixty AR patients diagnosed with an HDM allergy were tested for the presence of IgE antibodies against purified HDM allergen molecules (i.e., nDer p 1, rDer p 2, and rDer p 10) and native Dermatophagoides pteronyssinus (Dp) using ImmunoCAP 250®. Symptom scores and laboratory findings were analyzed after SLIT.
RESULTS
Prevalence rates of IgE for Dp, Der p 1, Der p 2, and Der p 10 were 100%, 98.3%, 93.3%, and 8.3%, respectively. After one year of immunotherapy with SLIToneâ—‹R (standardized to major allergens, but not Der p 10), symptom scores and laboratory findings improved in patients with and without Der p 10 IgE antibodies.
CONCLUSION
In Korean AR patients, specific IgE antibodies to Der p 1 or Der p 2 are present in most Dp-allergic patients, while reactivity to Der p 10 is very low. Allergic symptoms improved in patients with Der p 10 IgE antibodies after SLIT.

Keyword

Pyroglyphidae; Dermatophagoides pteronyssinus; Antigens, Dermatophagoides; Rhinitis, allergic; Sublingual immunotherapy

MeSH Terms

Allergens
Antibodies
Antigens, Dermatophagoides
Dermatophagoides pteronyssinus
Humans
Hypersensitivity
Immunoglobulin E*
Immunotherapy
Korea*
Prevalence
Pyroglyphidae
Rhinitis, Allergic*
Sublingual Immunotherapy
Allergens
Antibodies
Antigens, Dermatophagoides
Immunoglobulin E

Figure

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  Fig. 1. Specific IgE prevalences for Dp, Der p 1, Der p 2, and Der p 10 in proven house dust mite allergic rhinitis patients in Korea (n=60).

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  Fig. 2. Total symptom score (A) and rescue medication score (B) changes after one-year sublingual immunotherapy (SLIT) in Der p 10-positive (n=5) and -negative patients (n=55). Mean scores decreased significantly after one year of SLIT in both groups. *: paired t-test, †: Wilcoxon signed rank test.

Reference

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