Tissue Eng Regen Med.  2016 Dec;13(6):636-646. 10.1007/s13770-016-0125-8.

Current Status of Three-Dimensional Printing Inks for Soft Tissue Regeneration

Affiliations
  • 1KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, Korea.
  • 2Biomaterials Research Center, Korea Institute of Science and Technology, Seoul, Korea. winnie97@kist.re.kr
  • 3Department of Biomedical Engineering, University of Science and Technology (UST), Seoul, Korea.

Abstract

Recently, three-dimensional (3D) printing technologies have become an attractive manufacturing process, which is called additive manufacturing or rapid prototyping. A 3D printing system can design and fabricate 3D shapes and geometries resulting in custom 3D scaffolds in tissue engineering. In tissue regeneration and replacement, 3D printing systems have been frequently used with various biomaterials such as natural and synthetic polymers. In tissue engineering, soft tissue regeneration is very difficult because soft tissue has the properties of high elasticity, flexibility and viscosity which act as an obstacle when creating a 3D structure by stacking layer after layer of biomaterials compared to hard tissue regeneration. To overcome these limitations, many studies are trying to fabricate constructs with a very similar native micro-environmental property for a complex biofunctional scaffold with suitable biological and mechanical parameters by optimizing the biomaterials, for example, control the concentration and diversification of materials. In this review, we describe the characteristics of printing biomaterials such as hydrogel, synthetic polymer and composite type as well as recent advances in soft tissue regeneration. It is expected that 3D printed constructs will be able to replace as well as regenerate defective tissues or injured functional tissues and organs.

Keyword

Three-dimensional printing material; Soft tissue regeneration; Tissue engineering; Hydrogel; Three-dimensional bioprinting

MeSH Terms

Biocompatible Materials
Elasticity
Hydrogel
Ink*
Pliability
Polymers
Printing, Three-Dimensional*
Regeneration*
Tissue Engineering
Viscosity
Biocompatible Materials
Hydrogel
Polymers
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