Ann Dermatol.  1996 Jul;8(3):187-194. 10.5021/ad.1996.8.3.187.

Determination of Minimum Inhibitory Concentrations of Several Azole Antifungals for Malassezia furfur

• Ahn KJ
• Ashbee HR

• KMID: 2360488
• DOI: http://doi.org/10.5021/ad.1996.8.3.187

Abstract

BACKGROUND
There have been several reports which assessed the activity of antifungals including azoles on Malassezia furfur by agar dilution method. However, they did not differentiate M. furfur into groups. In addition, the media for growth and minimum inhibitory concentration (MIC) determination, incubation temperature and length of incubation differed from each other.
OBJECTIVE
The aim of this study was to test the antifungal activities of miconazole, clotrimazole, ketoconazole and itraconazole by determining MICs for M. furfur serovars A, B and C for these drugs.
METHODS
MICs were determined by the agar dilution method. Leeming & Notman's Malassezia furfur agar medium was used.
RESULTS
In all strains of serovars A, B and C, the MICs for miconazole were similar to those for clotrimazole ; MICs for ketoconazole were also similar to those for itraconazole ; MICs for miconazole or clotrimazole were higher than those for ketoconazole or itraconazole.
CONCLUSION
The results suggested that ketoconazole or itraconazole could be used more effectively than miconazole or clotrimazole for the treatment of the diseases caused by M. furfur.

Keyword

M.furfur; Serovars A, B and C; Azoles; MICs

MeSH Terms

Agar
Azoles
Clotrimazole
Danazol*
Itraconazole
Ketoconazole
Malassezia*
Methods
Miconazole
Microbial Sensitivity Tests*
Serogroup
Agar
Azoles
Clotrimazole
Danazol
Itraconazole
Ketoconazole
Miconazole