J Korean Radiol Soc.  1990 Aug;26(4):624-631. 10.3348/jkrs.1990.26.4.624.

Transarterial chemoembolization of hepatocellular carcinoma: one year survival rate of 193 cases

• Han JK
• Park JH
• Kim HS
• Park KS
• Lee G
• Kim SH
• Choi BI
• Han MC
• Lee HS
• Kim CY

• KMID: 2359472
• DOI: http://doi.org/10.3348/jkrs.1990.26.4.624

Abstract

Hepatocellular carcinoma(HCC) is one of the most common malignancies in Korea. Despite of recent advances indiagnostic and surgical technics, early diagnosis of HCC is difficult and chanced of surgical resection is stillvery low because of the multiplicity of tumors and assocaited liver cirrhosis. Transarterialchemo embolization(TAE) is a proven effective mean of treating HCC whether it is operable or not. The authorsanalyzed the survival data from 193 patients of HCC who were diagnosed and had undergone TAE in Seoul NationalUniversity Hospital from February 1987 to January 1988. Methods of TAE were the infusion of mixtuer of Lipiodol and Adriamycin with or without following administration of Gelfoam soaked in Mitomycin C. One year survival rateof all 193 cases was 53%. One year survival rate was affected by the presenced and the degree of arteriovenous(AV)fistula as well as Child class, stage of the disease and degree of portal vein involvement. One year survival ratewas 55.0% for Child class A, 46.9% for class B, 35% for class C, and 58.4% for stage I, 46.9% for stage II, and38.0% for stage III. Patients who had the involvement of main portal vein revealed one year survival rate of30.6%, whereas 44.1% for thte patients who had the involvement of first order branch and 60.5% for the patientswho had no involvement of portal vein or involvement was noted in smaller branches. Patients who had AV fistula ofgrade (++) and one year survival rate of 18.5%, 27.6% for (+) group, and 60.1% for (-) group. Patients who had undergone Gelfoam embolization after the infusion of Lipiodol-Adriamycin mixture had one year survival rate of57.3% whereas who had not undergone gelfoam embolization revealed one year survival rate of 47%. These resultssuggest that TAE is a very effective mean of treating HCC and the presence of AV firstula in one on the poorprognostic factors of HCC. Although this study lacks comparison between the same clinical groups, it is suggestedthat Gelfoam embolization after the infusion of Lipiodol-Adriamycin mixtuer may improve the prognosis of thepatients.

MeSH Terms

Carcinoma, Hepatocellular*
Child
Doxorubicin
Early Diagnosis
Ethiodized Oil
Fistula
Gelatin Sponge, Absorbable
Humans
Korea
Liver Cirrhosis
Mitomycin
Portal Vein
Prognosis
Seoul
Survival Rate*
Doxorubicin
Ethiodized Oil
Mitomycin