J Korean Radiol Soc.  1988 Jun;24(3):349-357. 10.3348/jkrs.1988.24.3.349.

Clinical trial of non-ionic contrast media

• Lee GJ
• Kim SH
• Park JH
• Chang KH
• Han MC
• Kim CW

• KMID: 2359258
• DOI: http://doi.org/10.3348/jkrs.1988.24.3.349

Abstract

Non-ionic contrast media, iopromide(Ultravist) was compared with ioxitalamate(Telebrix) and/orioxaglaate(Hexabrix) for efficacy and safety in 203 patients undergoinng cardiac angiography, neurovascularangiography, peripheral and visceral angiography and intravenous pyelography. In all patients, adverse symptoms and signs including heat sense, pain, nausea, vomiting, etc. were checked during and after the injection. In addition, EKG and LV pressure were monitored during the cardiac angiography. And also CBC,UA, BUN and creatininewere checked before and 24 hours after the cardiac angiography. Serious adverse effect did not occur in any case.Minor effects, such as nausea and abdominal pain, were less frequently caused by non-ionic contrast media than byionic contrast media, especialy in cardiac angiography and intravenous pyelography. There was no significantdifference between ionic and non-ionic contrast media in regard to electrophsiologic parameters such as EKG and LVpresssure. In case of intravenous pyelography, nonionic contrast media seemmed to be superior to ionic contrastmedia in image quality. It is suggested that, in spite of higher cost, non-ionic contrast media be needed for the safety and image quality, particularly in those patients at high risk of adverse effects by ionic contrast media.

MeSH Terms

Abdominal Pain
Angiography
Contrast Media*
Electrocardiography
Hot Temperature
Humans
Nausea
Urography
Vomiting
Contrast Media