Korean J Anesthesiol.  1977 Dec;10(2):203-208.

Serum Testosterone in Man during Methoxyflurane Anesthesia and Surgery

• Park SJ
• Chon SU

Abstract

The relationship between the Leydig cell of testis and the tropic hormones of the anterior pituitary gland has been inadequately explored in man because of methodological difficulties. A report has appeared on the effect of anesthesia per se on sex hormone levels in human serum. As testosterone is one of the most important anabolic hormones, it would therefore serve as an index to hormonal response to stress in man. Tcsticular blood level of testcsterone in man was increased by ether anesthesia but plasma testcsterone one in man was decreased by halothane anesthesia. Plasma testostercne levels were measured by others. by a competitive protein binding method. This study was performed to investigate the effect of methoxyflurane anesthesia and surgery on human sex hormone by a radioimmunoassay method. Serum testosterone levels measured in the pre-anesthetic period, (60 minutes after anesthesia and surgery, and at full recovery from. anesthesia were 3.80+/-1. 75 ng/ml, 0. 58+/-1. 22 ng/ml and 3. 55+/-1. 85 ng/ml, respectively. No statistical significance was observed. The obtained value of testostercne was the lowest when compared with the values reported by others.

MeSH Terms

Anesthesia*
Ether
Halothane
Humans
Methods
Methoxyflurane*
Pituitary Gland, Anterior
Plasma
Protein Binding
Radioimmunoassay
Testis
Testosterone*
Ether
Halothane
Methoxyflurane
Testosterone