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Relationship between Hypogonadal Symptoms, Sexual Dysfunction and Chronic Prostatitis in Middle-Aged Men by Self-Reported Questionnaires, even without Biochemical Testosterone Deficiency

Lee MH, Seo DH, Lee CW, Choi JH, Jeh SU, Lee SW, Choi SM, Hwa JS, Hyun JS, Chung KH, Kam SC

PURPOSE: To investigate the association of erectile dysfunction (ED), premature ejaculation (PE), and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in men with late-onset hypogonadism (LOH). MATERIALS AND METHODS: We reviewed the...
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Testosterone and Dehydroepiandrosterone Treatment in Ageing Men: Are We All Set?

Walther A, Seuffert J

Although demographic statistics show that populations around the world are rapidly ageing, this rising life expectancy is accompanied by an increase in the number of people living with age-related chronic...
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Testosterone Replacement Therapy for Patients with Hypogonadism after High Dose-Rate Brachytherapy for High-Risk Prostate Cancer: A Report of Six Cases and Literature Review

Kadomoto S, Shigehara , Iwamoto H, Yaegashi H, Izumi K, Kadono Y, Mizokami A

We had six cases of patients who were treated with long-term testosterone replacement therapy (TRT) after high dose-rate (HDR) brachytherapy and androgen deprivation therapy for high-risk prostate cancer. All patients...
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Cross-Sectional Association of Metabolic Syndrome and Its Components with Serum Testosterone Levels in a Korean-Screened Population

Kim M, Kyung YS, Ahn TY

PURPOSE: We evaluated the associations of metabolic syndrome (MetS) and its components with testosterone levels in the Korean population. MATERIALS AND METHODS: This cross-sectional study was performed among 6,967 adult (age≥20...
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Long-Term Testosterone Therapy in Type 2 Diabetes Is Associated with Decreasing Waist Circumference and Improving Erectile Function

Hackett G, Cole N, Mulay A, Strange RC, Ramachandran S

PURPOSE: To describe the 4-year metabolic follow-up results from the BLAST study. MATERIALS AND METHODS: Baseline hemoglobin A1c (HbA1c), weight, and waist circumference (WC) data were recorded in 185 men recruited...
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Associations of Metabolic Syndrome with Total Testosterone and Homocysteine Levels in Male Korean Workers

Sung SH, Kim NH, Hong SP, Lee JK, Choi SJ

BACKGROUND: Low testosterone is associated with metabolic syndrome (MetS), and homocysteine (Hcy) is elevated in individuals with MetS. We investigated the relationships of total testosterone (TT) and serum Hcy levels...
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C-Type Natriuretic Peptide/Natriuretic Peptide Receptor 2 Is Involved in Cell Proliferation and Testosterone Production in Mouse Leydig Cells

Yang L, Lei L, Zhao Q, Gong Y, Guan G, Huang S

PURPOSE: This study investigated the role of natriuretic peptide receptor 2 (NPR2) on cell proliferation and testosterone secretion in mouse Leydig cells. MATERIALS AND METHODS: Mouse testis of different postnatal stages...
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Misuse of testosterone replacement therapy in men in infertile couples and its influence on infertility treatment

Song SH, Sung S, Her YS, Oh M, Shin DH, Lee J, Baek J, Lee WS, Kim DS

OBJECTIVE: We investigated the clinical characteristics of men with testosterone replacement therapy (TRT)-induced hypogonadism and its effect on assisted reproductive technology (ART) in infertile couples. METHODS: This study examined the records...
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Testosterone Is a Contraceptive and Should Not Be Used in Men Who Desire Fertility

Patel AS, Leong JY, Ramos L, Ramasamy R

Testosterone has a variety of functions and is commonly used in older men to treat symptoms of hypogonadism, such as decreased libido, decreased mood and erectile dysfunction. Despite its positive...
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Type 2 Diabetes and Testosterone Therapy

Hackett G

A third of men with type 2 diabetes (T2DM) have hypogonadotrophic hypogonadism (HH) and associated increased risk of cardiovascular and all-cause mortality. Men with HH are at increased risk of...
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Obstructive Sleep Apnea and Testosterone Deficiency

Kim SD, Cho KS

Obstructive sleep apnea (OSA) is a common disorder characterized by intermittent hypoxia and sleep fragmentation. OSA in middle-aged men is often associated with decreased testosterone secretion, together with obesity and...
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Inhibitory effects of Pycnogenol®, a pine bark extract, in a rat model of testosterone propionate-induced benign prostatic hyperplasia

Ko JW, Park SW, Shin NR, Kim WI, Kim JC, Shin IS, Shin DH

Benign prostate hyperplasia (BPH) is a male reproductive disease that has gained increasing importance in recent years. The present study investigated whether Pycnogenol® (PYC), a standardized French maritime pine bark...
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Efficacy and Safety of a Mixed Extract of Trigonella foenum-graecum Seed and Lespedeza cuneata in the Treatment of Testosterone Deficiency Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Park HJ, Lee KS, Lee EK, Park NC

PURPOSE: The aim of this study was to investigate the efficacy and safety of a mixed extract of Trigonella foenum-graecum seed and Lespedeza cuneata (TFGL) for the treatment of testosterone...
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Impact of Testosterone Deficiency and Testosterone Therapy on Lower Urinary Tract Symptoms in Men with Metabolic Syndrome

Traish AM, Johansen V

Lower urinary tract function is modulated by neural, vascular and urethral and bladder structural elements. The pathophysiological mechanisms of lower urinary tract symptoms (LUTS) encompass prostate enlargement, alterations in urethra...
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Testosterone and Sarcopenia

Shin MJ, Jeon YK, Kim IJ

Aging affects metabolism, leading to physiological and functional impairments, and is also related to changes in body composition, including reduced skeletal muscle mass and increased body fat. These changes are...
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Which Exercise Is Better for Increasing Serum Testosterone Levels in Patients with Erectile Dysfunction?

Yeo JK, Cho SI, Park SG, Jo S, Ha JK, Lee JW, Cho SY, Park MG

PURPOSE: We investigated the correlations of serum total testosterone (TT) levels with body composition and physical fitness parameters in patients with erectile dysfunction (ED) to know the best exercise for...
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Testosterone Replacement, Muscle Strength, and Physical Function

Nam YS, Lee G, Yun JM, Cho B

Muscle strength and physical function decrease in older men, as do testosterone levels. Nonetheless, the effects of testosterone replacement therapy on muscle strength and physical function remain inconclusive and equivocal....
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Shifting the Paradigm of Testosterone Replacement Therapy in Prostate Cancer

Bell MA, Campbell J, Joice G, Sopko NA, Burnett AL

Historically, testosterone and prostate cancer have been demonstrated to have a positive association leading providers to forgo testosterone replacement therapy (TRT) in men with concurrent histories of hypogonadism and prostate...
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Emerging Evidences in the Long Standing Controversy Regarding Testosterone Replacement Therapy and Cardiovascular Events

Clavell-Hernández J, Wang R

The increasing rate of late-onset hypogonadism has led to an exceptional growth in the use of testosterone therapy (TTh). Even though TTh has been used for more than 70 years,...
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Hypogonadal men with moderate-to-severe lower urinary tract symptoms have a more severe cardiometabolic risk profile and benefit more from testosterone therapy than men with mild lower urinary tract symptoms

Saad F, Doros G, Haider KS, Haider A

PURPOSE: To analyze data from an observational, prospective, cumulative registry study in 805 hypogonadal men stratified by mild or moderate-to-severe lower urinary tract symptoms (LUTS) according to International Prostate Symptom...
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