Korean J Anesthesiol.  1978 Dec;11(4):340-350.

The Effects of Propanidid-Ketamine Anesthesia on Cardiovascular and Respiratory Systems of Rabbits

• Choi JY

Abstract

There is a definite need for safe and potent intravenously administered anesthetics of .short duration which combine analgesic and sleep-producing effects without significant cardiovascular and respiratory depression. There are many intravenous drugs to choose from and there have been many types of balanced anesthesia, but no one is satisfactory yet. This experimental study was carried out to seek the possibility of some improved features of cardiovascular and respiratory systems, with the combination of propanidid and ketamine, using rabbits as experimental animals. The following results were obtained. 1) Propanidid is freely miscible with ketamine without significant change of pH, colour or any sediment, so it seems that the effects of both drugs may be preserved well. 2) The propanidid-ketamine mixture group shows that ketamine compensates for the depressive effect of propanidid on blood pressure and pulse rate. 3) The propanidid-ketamine mixture group shows that ketamine compensates for the respiratory depression of propanidid to some extent and propanidid alleviates increased muscle tone by ketamine. Taking together the present results, ketamine compensates well the for depressive effects of propanidid on the cardiovascular and respiratory systems. Thus propanidid-ketamine mixture seems to be a suitable anesthetic.

MeSH Terms

Anesthesia*
Anesthetics
Animals
Balanced Anesthesia
Blood Pressure
Heart Rate
Hydrogen-Ion Concentration
Ketamine
Propanidid
Rabbits*
Respiratory Insufficiency
Respiratory System*
Anesthetics
Ketamine
Propanidid