Arch Aesthetic Plast Surg.  2016 Oct;22(3):129-134. 10.14730/aaps.2016.22.3.129.

The Effects of Vascular Endothelial Growth Factor on Capsule Formation around Silicone Implant in Rats

• Kim DH
• Song YS
• Song SY
• Kim CH

• KMID: 2356762
• DOI: http://doi.org/10.14730/aaps.2016.22.3.129

Abstract

BACKGROUND
The purpose of this study was to examine the effects of a single administration of vascular endothelial growth factor (VEGF) in promoting the angiogenesis and thereby reducing the formation of capsular contracture.
METHODS
We treated 24 female Sprague-Dawley rats with (1) 5 mM Tris Buffer and 150 mM NaCl 0.1 cc, (2) VEGF 15 µg/0.1 cc, (3) VEGF 150 µg/0.1 cc during placement of the implant, or (4) VEGF 150 µg/0.1 cc and VEGF 300 µg/0.2 cc. We histopathologically measured the thickness of the capsule and the number of blood vessels.
RESULTS
All experimental groups had a significant difference in the thickness of the capsule compared to the control group (P<0.001). There was no significant difference between experimental group 2 and experimental group 3. The number of blood vessels formed around the capsule was significantly greater in all the experimental groups compared with the control group (P<0.05). There was no significant difference between the experimental groups. There was a significant negative correlation between the thickness of the capsule and the number of blood vessels (Spearman's correlation coefficient, 0.2732; P<0.0001).
CONCLUSIONS
A single administration of VEGF reduced formation of the capsule and increased the vascularity around the implant, supporting the hypothesis that prevention of tissue ischemia can be a treatment strategy for capsular contracture.

Keyword

Breast implants; Contracture; Rats; Vascular endothelial growth factor

MeSH Terms

Animals
Blood Vessels
Breast Implants
Contracture
Female
Humans
Ischemia
Rats*
Rats, Sprague-Dawley
Silicon*
Silicones*
Tromethamine
Vascular Endothelial Growth Factor A*
Silicon
Silicones
Tromethamine
Vascular Endothelial Growth Factor A