Nucl Med Mol Imaging.
2016 Sep;50(3):270-272. 10.1007/s13139-015-0375-8.
False-Positive Radioactive Iodine Uptake Mimicking Miliary Lung Metastases in a Patient Affected by Papillary Thyroid Cancer and IgA Deficiency
- Affiliations
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- 1Section on Growth and Obesity, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 9000 Rockville Pk, Building 10/1-3330, Bethesda, MD 20892-1
- 2Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
- 3Nuclear Medicine Division, Radiology and Imaging Sciences Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
- 4Division of Endocrinology and Metabolism, Virginia Commonwealth University, Richmond, VA, USA.
- KMID: 2351654
- DOI: http://doi.org/10.1007/s13139-015-0375-8
Abstract
- A 42-year-old female with immunoglobulin A deficiency and recurrent sinopulmonary infections underwent thyroidectomy for papillary thyroid cancer (PTC). Follow-up ¹²³I scintigraphy demonstrated diffuse pulmonary uptake, suggesting metastatic disease. However, subsequent pathologic, biochemical and radiographic testing proved that she was in fact disease free, and the initial ¹²³I pulmonary uptake was identified as a false positive. Inflammatory conditions may rarely cause iodine uptake in non-thyroidal tissues due to local retention, organification, and/or immunologic utilization. To avoid exposing patients to unnecessary treatments, it is critical for clinicians to recognize that comorbid pulmonary conditions may mimic metastatic PTC on radioiodine scintigraphy.
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