Korean J Dermatol.  2016 Aug;54(7):552-556.

A Case of Woringer-Kolopp Disease of the Hand

Affiliations
  • 1Department of Dermatology, Gachon University, Gil Medical Center, Incheon, Korea. jobaek79@gmail.com
  • 2Department of Pathology, Gachon University, Gil Medical Center, Incheon, Korea.

Abstract

Woringer-Kolopp disease, also known as localized pagetoid reticulosis, is a rare variant of mycosis fungoides that presents as a solitary localized hyperkeratotic patch or plaque on the extremities and follows a benign course. Effective treatments for Woringer-Kolopp disease include skin-directed therapies such as topical nitrogen mustard, high-potency topical steroids, and phototherapy. Surgical excision has been pursued in cases of small, localized lesions. A 39-year-old man presented with a 3-month history of an asymptomatic plaque on his hand. Physical examination showed a 10-mm-diameter solitary round erythematous hyperkeratotic plaque with a slightly raised edge on the dorsum of his left hand. A skin biopsy revealed that numerous atypical lymphocytes had infiltrated the upper dermis and expanded into the epidermis with a pagetoid pattern. These atypical pagetoid cells were strongly positive for CD3, CD8, and T-cell intracellular antigen-1; focally positive for CD4; and negative for CD20, CD30, and CD56. A subsequent general examination revealed no evidence of systemic involvement and the lesion was treated with surgical excision. Here we report a rare case of Woringer-Kolopp disease.

Keyword

Woringer-Kolopp disease; Pagetoid reticulosis

MeSH Terms

Adult
Biopsy
Dermis
Epidermis
Extremities
Hand*
Humans
Lymphocytes
Mechlorethamine
Mycosis Fungoides
Pagetoid Reticulosis*
Phototherapy
Physical Examination
Skin
Steroids
T-Lymphocytes
Mechlorethamine
Steroids
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