Clin Psychopharmacol Neurosci.  2016 Aug;14(3):231-237. 10.9758/cpn.2016.14.3.231.

Fecal Microbiota Transplantation and Its Usage in Neuropsychiatric Disorders

• Evrensel A
• Ceylan ME

• KMID: 2348470
• DOI: http://doi.org/10.9758/cpn.2016.14.3.231

Abstract

Fecal microbiota transplantation has a 1700-year history. This forgotten treatment method has been put into use again during the last 50 years. The interest in microbiota-gut-brain axis and fecal microbiota transplantation is rapidly increasing. New evidence is obtained in the etiopathogenesis of neuropsychiatric disorders. There is a large number of experimental and clinical researches in the field of gut-brain axis. There is limited information on fecal microbiota transplantation. Despite this, initial results are promising. It is commonly used in the treatment of gastrointestinal diseases such as Clostridium difficile infection, Crohn's disease, ulcerative colitis. It is also experimentally used in the treatment of metabolic and autoimmune diseases. There are case reports that it is effective in the treatment of autism, Parkinson's disease, multiple sclerosis, chronic fatigue syndrome and irritable bowel syndrome. Its implementation is easy, and it is a cheap and reliable treatment method. However, the long-term risks are unknown. Additionally, standard application protocols have not yet been established. There are a lot of questions to be answered. A university in Turkey has got official permission this year, and started to apply fecal microbiota transplantation. In this review, neuropsychiatric areas of use of fecal microbiota transplantation have been discussed in the light of the current information.

Keyword

Fecal microbiota transplantation; Psychiatry; Neurology; Immune system; Gut-brain axis

MeSH Terms

Autistic Disorder
Autoimmune Diseases
Clostridium difficile
Colitis, Ulcerative
Crohn Disease
Fatigue Syndrome, Chronic
Fecal Microbiota Transplantation*
Gastrointestinal Diseases
Immune System
Irritable Bowel Syndrome
Methods
Multiple Sclerosis
Neurology
Parkinson Disease
Turkey