J Korean Dent Soc Anesthesiol.  2012 Jun;12(2):69-74. 10.17245/jkdsa.2012.12.2.69.

A Prospective, Randomized and Controlled Study for the Efficacy and Safety of Sedation Technique for Implant Surgery by Combining Nitrous Oxide and Intravenous Midazolam

Affiliations
  • 1Division of Oral and Maxillofacial Surgery, College of Medicine, Hanyang University, Seoul, Korea. fastchang@hanyang.ac.kr
  • 2Division of Conservative Dentistry, College of Medicine, Hanyang University, Seoul, Korea.
  • 3Division of Preventive Dentistry, Department of Dentistry, College of Medicine, Hanyang University, Seoul, Korea.
  • 4Department of Oral and Maxillofacial Surgery, Korea University Anam Hospital, Korea University, Seoul, Korea.

Abstract

BACKGROUND
The purpose of this study is to investigate the efficacy and safety of the sedation technique for implant surgery by combining the use of inhalation of nitrous oxide/oxygen with intravenous midazolam.
METHODS
Patients requiring surgery for the placement of dental implants were randomly allocated to two groups receiving intravenous midazolam or a combined technique using nitrous oxide/oxide and intravenous midazolam. Safety parameters, cooperation scores, anxiety scales, total amount of midazolam administered and recovery time were recorded and compared.
RESULTS
There were a statistically significant reduction in the amount of midazolam required to achieve optimal sedation (P<0.01), an overall significant reduction in recovery time (P<0.01), a significant reduction in anxiety scales (P<0.05), and a significant improvement in cooperation (P<0.05) and peripheral oxygen saturation (P<0.05) when a combined technique of inhalational N2O/O2 and midazolam was used.
CONCLUSIONS
For implant surgery, this combining sedation technique could be safe and reliable, demonstrating reduction of total dose of midazolam and level of patient's anxiety and improvement in patient's recovery and cooperation.

Keyword

Anesthetics, inhalation; Anesthetics, intravenous; Conscious sedation; Dental implants; midazolam; Nitrous oxide

MeSH Terms

Anesthetics, Inhalation
Anesthetics, Intravenous
Anxiety
Conscious Sedation
Dental Implants
Humans
Inhalation
Midazolam*
Nitrous Oxide*
Oxygen
Prospective Studies*
Weights and Measures
Anesthetics, Inhalation
Anesthetics, Intravenous
Dental Implants
Midazolam
Nitrous Oxide
Oxygen
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