J Korean Dent Soc Anesthesiol.
2013 Sep;13(3):89-94. 10.17245/jkdsa.2013.13.3.89.
EC50 of Remifentanil to Prevent Propofol Injection Pain
- Affiliations
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- 1Department of Dental Anesthesia and Pain Medicine, School of Dentistry, Pusan National University, Busan, Korea. dryoonji@pusan.ac.kr
- 2Department of Anesthesia and Pain Medicine School of Medicine, Pusan National University, Busan, Korea.
- 3Department of Oral and Maxillofacial Surgery School of Dentistry, Pusan National University, Busan, Korea.
- KMID: 2345018
- DOI: http://doi.org/10.17245/jkdsa.2013.13.3.89
Abstract
- BACKGROUND
Various strategies have been studied to reduce the propofol injection pain. This study was designed to find out effect-site target concentration (Ce) of remifentanil at which there was a 50% probability of preventing the propofol injection pain (EC50).
METHODS
Anesthesia was induced with a remifentanil TCI (Minto model). The Ce of remifentanil for the first patient started from 2.0 ng/ml. The Ce of remifentanil for each subsequent patient was determined by the response of the previous patient by Dixon up-and-down method with the interval of 0.5 ng/ml. After the remifentanil reached target concentrations, propofol was administered via a target-controlled infusion system based on a Marsh pharmacokinetic model using a TCI device (Orchestra®; Fresenius-Vial, Brezins, France). The dose of propofol was effect site target-controlled infusion (TCI) of 3 µg/ml.
RESULTS
The EC50 of remifentanil to prevent the propofol injection pain was 1.80 ± 0.35 ng/ml by Dixon's up and down method.
CONCLUSIONS
The EC50 of remifentanil to blunt the pain responses to propofol injection was 1.80 ± 0.35 ng/ml for propofol TCI anesthesia.
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