J Korean Neurol Assoc.  2008 Nov;26(4):333-340.

Cognitive Dysfunctions in Patients With Severe Obstructive Sleep Apnea Syndrome: Neuropsychological Test and Event-Related Potential Study

• Lee DK
• Park HJ
• Kim SH
• Cho JW
• Joo EY
• Jung KY
• Hong SB

Abstract

BACKGROUND
Patients with obstructive sleep apnea syndrome (OSAS) show variety of dysfunctions in cognitions including general cognitive function, attention, and frontal lobe and executive function. However, there is no consensus on the main features of the cognitive dysfunction in OSAS patients. So we performed neuropsychological tests and event-related potential (ERP) studies in patients with severe OSAS to evaluate the cognitive dysfunctions and changes of auditory and visual P300.
METHODS
Twenty-eight men with severe OSAS (apnea hypopnea index (AHI)=63.1+/-17.8/hr) and 16 age, sex, education- matched normal controls (AHI=2.9+/-1.8/hr) underwent neuropsychological tests and ERP studies.
RESULTS
Patients with severe OSAS showed deficits in corsi block forward and backward test during neuropsychological evaluation, and delayed latency and decreased amplitude of auditory P300. There were significant correlations between auditory P300 amplitudes and digit span forward or corsi block forward test scores, and between visual P300 amplitudes and digit symbol test scores.
CONCLUSIONS
These findings suggest that severe OSAS patients may have deficits in attention and short-term memory, and abnormal auditory P300.

Keyword

Obstructive sleep apnea; Cognition; Attention; Neuropsychological test; Event-related potentials; P300

MeSH Terms

Cognition
Consensus
Evoked Potentials
Executive Function
Frontal Lobe
Humans
Male
Memory, Short-Term
Neuropsychological Tests
Sleep Apnea, Obstructive